The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis

The mitochondrial protein IF1 binds to the catalytic domain of the ATP synthase and inhibits ATP hydrolysis in ischemic tissues. Moreover, IF1 is overexpressed in many tumors and has been shown to act as a pro-oncogenic protein, although its mechanism of action is still debated. Here, we show that A...

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Detalles Bibliográficos
Autores principales: Galber, Chiara, Fabbian, Simone, Gatto, Cristina, Grandi, Martina, Carissimi, Stefania, Acosta, Manuel Jesus, Sgarbi, Gianluca, Tiso, Natascia, Argenton, Francesco, Solaini, Giancarlo, Baracca, Alessandra, Bellanda, Massimo, Giorgio, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870916/
https://www.ncbi.nlm.nih.gov/pubmed/36690622
http://dx.doi.org/10.1038/s41419-023-05572-y

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