The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice

Hepatocellular death increases with hepatic steatosis aggravation, although its regulation remains unclear. Here we show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis to necroptosis, causing increased hepatocellular death. Our results reveal that the transcri...

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Detalles Bibliográficos
Autores principales: Inaba, Yuka, Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Oshima, Yu, Tsuchiya, Kohsuke, Murai, Shin, Takahashi, Chiaki, Matsumoto, Michihiro, Kitajima, Shigetaka, Yamamoto, Yasuhiko, Honda, Masao, Asahara, Shun-ichiro, Ravnskjaer, Kim, Horike, Shin-ichi, Kaneko, Shuichi, Kasuga, Masato, Nakano, Hiroyasu, Harada, Kenichi, Inoue, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871012/
https://www.ncbi.nlm.nih.gov/pubmed/36690638
http://dx.doi.org/10.1038/s41467-023-35804-w

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