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Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report
Aspergillus endocarditis (AE) is a highly fatal infection that can occur in heart valve replacement, pacemaker implantation and other heart surgeries, and early recognition and sufficient diagnosis are challenging. Here, we report the case of a 68-year-old male with a history of dilated cardiomyopat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871031/ https://www.ncbi.nlm.nih.gov/pubmed/36704772 http://dx.doi.org/10.2147/IDR.S393917 |
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author | Chen, Wanyuan Ji, Youqi Hong, Xin Zhu, Yongze Gou, Xiaoyu Chen, Mengyuan Lv, Huoyang Ge, Yumei |
author_facet | Chen, Wanyuan Ji, Youqi Hong, Xin Zhu, Yongze Gou, Xiaoyu Chen, Mengyuan Lv, Huoyang Ge, Yumei |
author_sort | Chen, Wanyuan |
collection | PubMed |
description | Aspergillus endocarditis (AE) is a highly fatal infection that can occur in heart valve replacement, pacemaker implantation and other heart surgeries, and early recognition and sufficient diagnosis are challenging. Here, we report the case of a 68-year-old male with a history of dilated cardiomyopathy and pacemaker implantation who had a repeated fever with failed antibacterial treatment and sterile blood culture. He developed endocarditis, and the culture and biopsy of vegetation tissue showed the abundant presence of septate hyphae, which was subsequently identified as Aspergillus fumigatus by internal transcribed spacer (ITS) sequencing. Although the patient had serious side effects from voriconazole, he had a good prognosis following surgery and prolonged caspofungin antifungal therapy of 42 consecutive days. We discuss the diagnosis and treatment strategy of AE, and recommend galactomannan assays and next-generation sequencing for a timely diagnosis. Early surgical intervention combined with prompt antifungal therapy appears significant for survival. |
format | Online Article Text |
id | pubmed-9871031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-98710312023-01-25 Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report Chen, Wanyuan Ji, Youqi Hong, Xin Zhu, Yongze Gou, Xiaoyu Chen, Mengyuan Lv, Huoyang Ge, Yumei Infect Drug Resist Case Report Aspergillus endocarditis (AE) is a highly fatal infection that can occur in heart valve replacement, pacemaker implantation and other heart surgeries, and early recognition and sufficient diagnosis are challenging. Here, we report the case of a 68-year-old male with a history of dilated cardiomyopathy and pacemaker implantation who had a repeated fever with failed antibacterial treatment and sterile blood culture. He developed endocarditis, and the culture and biopsy of vegetation tissue showed the abundant presence of septate hyphae, which was subsequently identified as Aspergillus fumigatus by internal transcribed spacer (ITS) sequencing. Although the patient had serious side effects from voriconazole, he had a good prognosis following surgery and prolonged caspofungin antifungal therapy of 42 consecutive days. We discuss the diagnosis and treatment strategy of AE, and recommend galactomannan assays and next-generation sequencing for a timely diagnosis. Early surgical intervention combined with prompt antifungal therapy appears significant for survival. Dove 2023-01-19 /pmc/articles/PMC9871031/ /pubmed/36704772 http://dx.doi.org/10.2147/IDR.S393917 Text en © 2023 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Report Chen, Wanyuan Ji, Youqi Hong, Xin Zhu, Yongze Gou, Xiaoyu Chen, Mengyuan Lv, Huoyang Ge, Yumei Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report |
title | Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report |
title_full | Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report |
title_fullStr | Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report |
title_full_unstemmed | Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report |
title_short | Pacemaker Associated Aspergillus fumigatus Endocarditis: A Case Report |
title_sort | pacemaker associated aspergillus fumigatus endocarditis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871031/ https://www.ncbi.nlm.nih.gov/pubmed/36704772 http://dx.doi.org/10.2147/IDR.S393917 |
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