Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

Interleukin-2 (IL-2) is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells (Tregs) and effector cells, leading to paradoxical consequences. Here, we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive arti...

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Sun, Jiaqi, Yuan, Yeshuang, Ji, Dezhong, Sun, Yeting, Liu, Yudong, Li, Shengjie, Zhu, Xingxing, Wu, Xunyao, Hu, Jin, Xie, Qiu, Wu, Ling, Liu, Lulu, Cheng, Boyang, Zhang, Yuanjie, Jiang, Lingjuan, Zhao, Lidan, Yu, Fei, Song, Wei, Wang, Min, Xu, Yue, Ma, Shiliang, Fei, Yunyun, Zhang, Lihe, Zhou, Demin, Zhang, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871032/
https://www.ncbi.nlm.nih.gov/pubmed/36690610
http://dx.doi.org/10.1038/s41392-022-01208-3

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