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Discovery of structural and functional transition sites for membrane-penetrating activity of sheep myeloid antimicrobial peptide-18

Cathelicidin antimicrobial peptides have an extended and/or unstructured conformation in aqueous solutions but fold into ordered conformations, such as the α-helical structure, when interacting with cellular membranes. These structural transitions can be directly correlated to their antimicrobial ac...

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Detalles Bibliográficos
Autores principales: Jung, Bomi, Yun, Hyosuk, Min, Hye Jung, Yang, Sungtae, Shin, Song Yub, Lee, Chul Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871035/
https://www.ncbi.nlm.nih.gov/pubmed/36690720
http://dx.doi.org/10.1038/s41598-023-28386-6