Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Glucokinase (GK, gene symbol GCK) maturity-onset diabetes of the young (MODY) is caused by heterozygous inactivating mutations in GK and impaired glucose sensing. We investigated effects of dorzagliatin, a novel allosteric GK activator, on insulin secretion rates (ISRs) and β-cell glucose sensitivit...

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Detalles Bibliográficos
Autores principales: Chow, Elaine, Wang, Ke, Lim, Cadmon K.P., Tsoi, Sandra T.F., Fan, Baoqi, Poon, Emily, Luk, Andrea O.Y., Ma, Ronald C.W., Ferrannini, Ele, Mari, Andrea, Chen, Li, Chan, Juliana C.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2023
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871194/
https://www.ncbi.nlm.nih.gov/pubmed/36342518
http://dx.doi.org/10.2337/db22-0708

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