Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head–bound state

KIF1A is an essential neuronal transport motor protein in the kinesin-3 family, known for its superprocessive motility. However, structural features underlying this function are unclear. Here, we determined that superprocessivity of KIF1A dimers originates from a unique structural domain, the lysine...

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Detalles Bibliográficos
Autores principales: Zaniewski, Taylor M., Hancock, William O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871336/
https://www.ncbi.nlm.nih.gov/pubmed/36549649
http://dx.doi.org/10.1016/j.jbc.2022.102818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871336/
https://www.ncbi.nlm.nih.gov/pubmed/36549649
http://dx.doi.org/10.1016/j.jbc.2022.102818

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