Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia

The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ferredoxin reductase (PFOR) and nitroreductase (NR) 1 which metabolize metronidazol...

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Detalles Bibliográficos
Autores principales: Saghaug, Christina S., Gamlem, Astrid L., Hauge, Kirsti B., Vahokoski, Juha, Klotz, Christian, Aebischer, Toni, Langeland, Nina, Hanevik, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871439/
https://www.ncbi.nlm.nih.gov/pubmed/36682328
http://dx.doi.org/10.1016/j.ijpddr.2022.12.003

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