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Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis
OBJECTIVE: Nighttime snacking is an effective intervention to avoid abnormal protein consumption caused by prolonged fasting. This article aims to evaluate the clinical efficacy of nighttime snacking on patients with hepatitis B cirrhosis and to provide new ideas for clinical nutritional interventio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871573/ https://www.ncbi.nlm.nih.gov/pubmed/36704800 http://dx.doi.org/10.3389/fnut.2022.999462 |
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author | Han, Zuoqing Li, Rongkuan Zhong, Zhiwei Piao, Yuetong Guo, Rong |
author_facet | Han, Zuoqing Li, Rongkuan Zhong, Zhiwei Piao, Yuetong Guo, Rong |
author_sort | Han, Zuoqing |
collection | PubMed |
description | OBJECTIVE: Nighttime snacking is an effective intervention to avoid abnormal protein consumption caused by prolonged fasting. This article aims to evaluate the clinical efficacy of nighttime snacking on patients with hepatitis B cirrhosis and to provide new ideas for clinical nutritional intervention. METHODS: The study participants were randomly assigned to the control group (n = 30) and the observation group (n = 30); the former was administered medical system treatment and routine dietary intervention, and the latter was administered the same treatment with the addition of nighttime snacking. After 3 months of intervention with different dietary guidance, the dry body weight body mass index (BMI), upper arm muscle circumference (AMC), grip strength, triceps skinfold thickness (TSF), third lumbar skeletal muscle index (L3-SMI), albumin (ALB), total bilirubin (T-BIL), cholinesterase (CHE), Fried's frailty phenotype score, Child–Pugh score and various cirrhosis complication rates were compared between the two groups. RESULTS: There was no significant difference in the baseline data between the two groups before the dietary intervention. After 3 months of regular dietary guidance in the control group, the grip strength increased compared with the baseline data (p < 0.05), while the dry body weight BMI, AMC, TSF, L3-SMI, ALB, T-BIL, CHE, prothrombin time, international normalized ratio, prothrombin activity, and Child–Pugh scores were not significantly different (p > 0.05). After 3 months of dietary guidance with nighttime snacking in the observation group, the dry body weight BMI, grip strength, TSF, L3-SMI, and CHE scores all increased, compared with the baseline data, while the Child–Pugh score decreased compared with the baseline level (all p < 0.05). After 3 months of intervention, the Child–Pugh score of the observation group showed a more significant decrease than the control group, while the dry body weight BMI, grip strength, ALB and CHE scores were all significantly higher than those in the control group (all p < 0.05). Overall, the improvement rate was significantly higher in the observation group than in the control group (p < 0.05). CONCLUSION: Nighttime snacking for hepatitis B cirrhosis patients with nutritional risk is beneficial in terms of the recovery of liver synthesis functions, improvements in clinical indicators, sarcopenia corrections and improvements in malnutrition-related complications. |
format | Online Article Text |
id | pubmed-9871573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98715732023-01-25 Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis Han, Zuoqing Li, Rongkuan Zhong, Zhiwei Piao, Yuetong Guo, Rong Front Nutr Nutrition OBJECTIVE: Nighttime snacking is an effective intervention to avoid abnormal protein consumption caused by prolonged fasting. This article aims to evaluate the clinical efficacy of nighttime snacking on patients with hepatitis B cirrhosis and to provide new ideas for clinical nutritional intervention. METHODS: The study participants were randomly assigned to the control group (n = 30) and the observation group (n = 30); the former was administered medical system treatment and routine dietary intervention, and the latter was administered the same treatment with the addition of nighttime snacking. After 3 months of intervention with different dietary guidance, the dry body weight body mass index (BMI), upper arm muscle circumference (AMC), grip strength, triceps skinfold thickness (TSF), third lumbar skeletal muscle index (L3-SMI), albumin (ALB), total bilirubin (T-BIL), cholinesterase (CHE), Fried's frailty phenotype score, Child–Pugh score and various cirrhosis complication rates were compared between the two groups. RESULTS: There was no significant difference in the baseline data between the two groups before the dietary intervention. After 3 months of regular dietary guidance in the control group, the grip strength increased compared with the baseline data (p < 0.05), while the dry body weight BMI, AMC, TSF, L3-SMI, ALB, T-BIL, CHE, prothrombin time, international normalized ratio, prothrombin activity, and Child–Pugh scores were not significantly different (p > 0.05). After 3 months of dietary guidance with nighttime snacking in the observation group, the dry body weight BMI, grip strength, TSF, L3-SMI, and CHE scores all increased, compared with the baseline data, while the Child–Pugh score decreased compared with the baseline level (all p < 0.05). After 3 months of intervention, the Child–Pugh score of the observation group showed a more significant decrease than the control group, while the dry body weight BMI, grip strength, ALB and CHE scores were all significantly higher than those in the control group (all p < 0.05). Overall, the improvement rate was significantly higher in the observation group than in the control group (p < 0.05). CONCLUSION: Nighttime snacking for hepatitis B cirrhosis patients with nutritional risk is beneficial in terms of the recovery of liver synthesis functions, improvements in clinical indicators, sarcopenia corrections and improvements in malnutrition-related complications. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9871573/ /pubmed/36704800 http://dx.doi.org/10.3389/fnut.2022.999462 Text en Copyright © 2023 Han, Li, Zhong, Piao and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Han, Zuoqing Li, Rongkuan Zhong, Zhiwei Piao, Yuetong Guo, Rong Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis |
title | Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis |
title_full | Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis |
title_fullStr | Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis |
title_full_unstemmed | Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis |
title_short | Clinical effect of nighttime snacking on patients with hepatitis B cirrhosis |
title_sort | clinical effect of nighttime snacking on patients with hepatitis b cirrhosis |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871573/ https://www.ncbi.nlm.nih.gov/pubmed/36704800 http://dx.doi.org/10.3389/fnut.2022.999462 |
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