Cargando…
Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets
Hypertension is regarded as the most prominent risk factor for cardiovascular diseases, which have become a primary cause of death, and recent research has demonstrated that chronic inflammation is involved in the pathogenesis of hypertension. Both innate and adaptive immunity are now known to promo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871625/ https://www.ncbi.nlm.nih.gov/pubmed/36703963 http://dx.doi.org/10.3389/fimmu.2022.1098725 |
_version_ | 1784877218584854528 |
---|---|
author | Zhang, Zenglei Zhao, Lin Zhou, Xingyu Meng, Xu Zhou, Xianliang |
author_facet | Zhang, Zenglei Zhao, Lin Zhou, Xingyu Meng, Xu Zhou, Xianliang |
author_sort | Zhang, Zenglei |
collection | PubMed |
description | Hypertension is regarded as the most prominent risk factor for cardiovascular diseases, which have become a primary cause of death, and recent research has demonstrated that chronic inflammation is involved in the pathogenesis of hypertension. Both innate and adaptive immunity are now known to promote the elevation of blood pressure by triggering vascular inflammation and microvascular remodeling. For example, as an important part of innate immune system, classically activated macrophages (M1), neutrophils, and dendritic cells contribute to hypertension by secreting inflammatory cy3tokines. In particular, interferon-gamma (IFN-γ) and interleukin-17 (IL-17) produced by activated T lymphocytes contribute to hypertension by inducing oxidative stress injury and endothelial dysfunction. However, the regulatory T cells and alternatively activated macrophages (M2) may have a protective role in hypertension. Although inflammation is related to hypertension, the exact mechanisms are complex and unclear. The present review aims to reveal the roles of inflammation, immunity, and oxidative stress in the initiation and evolution of hypertension. We envisage that the review will strengthen public understanding of the pathophysiological mechanisms of hypertension and may provide new insights and potential therapeutic strategies for hypertension. |
format | Online Article Text |
id | pubmed-9871625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98716252023-01-25 Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets Zhang, Zenglei Zhao, Lin Zhou, Xingyu Meng, Xu Zhou, Xianliang Front Immunol Immunology Hypertension is regarded as the most prominent risk factor for cardiovascular diseases, which have become a primary cause of death, and recent research has demonstrated that chronic inflammation is involved in the pathogenesis of hypertension. Both innate and adaptive immunity are now known to promote the elevation of blood pressure by triggering vascular inflammation and microvascular remodeling. For example, as an important part of innate immune system, classically activated macrophages (M1), neutrophils, and dendritic cells contribute to hypertension by secreting inflammatory cy3tokines. In particular, interferon-gamma (IFN-γ) and interleukin-17 (IL-17) produced by activated T lymphocytes contribute to hypertension by inducing oxidative stress injury and endothelial dysfunction. However, the regulatory T cells and alternatively activated macrophages (M2) may have a protective role in hypertension. Although inflammation is related to hypertension, the exact mechanisms are complex and unclear. The present review aims to reveal the roles of inflammation, immunity, and oxidative stress in the initiation and evolution of hypertension. We envisage that the review will strengthen public understanding of the pathophysiological mechanisms of hypertension and may provide new insights and potential therapeutic strategies for hypertension. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9871625/ /pubmed/36703963 http://dx.doi.org/10.3389/fimmu.2022.1098725 Text en Copyright © 2023 Zhang, Zhao, Zhou, Meng and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Zenglei Zhao, Lin Zhou, Xingyu Meng, Xu Zhou, Xianliang Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets |
title | Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets |
title_full | Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets |
title_fullStr | Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets |
title_full_unstemmed | Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets |
title_short | Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets |
title_sort | role of inflammation, immunity, and oxidative stress in hypertension: new insights and potential therapeutic targets |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871625/ https://www.ncbi.nlm.nih.gov/pubmed/36703963 http://dx.doi.org/10.3389/fimmu.2022.1098725 |
work_keys_str_mv | AT zhangzenglei roleofinflammationimmunityandoxidativestressinhypertensionnewinsightsandpotentialtherapeutictargets AT zhaolin roleofinflammationimmunityandoxidativestressinhypertensionnewinsightsandpotentialtherapeutictargets AT zhouxingyu roleofinflammationimmunityandoxidativestressinhypertensionnewinsightsandpotentialtherapeutictargets AT mengxu roleofinflammationimmunityandoxidativestressinhypertensionnewinsightsandpotentialtherapeutictargets AT zhouxianliang roleofinflammationimmunityandoxidativestressinhypertensionnewinsightsandpotentialtherapeutictargets |