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Cardiovascular and metabolic determinants of quality of life in patients with cancer
AIMS: Maintaining quality of life (QoL) in patients with cancer has gathered significant interest, but little is known about its major determinants. We sought to identify determinants of QoL in patients undergoing cancer treatment as well as in treatment‐naïve patients about to commence such therapy...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871717/ https://www.ncbi.nlm.nih.gov/pubmed/36178215 http://dx.doi.org/10.1002/ehf2.14175 |
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author | Evertz, Ruben Gödde, Katharina Diehl, Christine Valentova, Miroslava Garfias‐Veitl, Tania Braulke, Friederike Wulf, Gerald G. Overbeck, Tobias R. Bleckmann, Annalen König, Alexander O. Weinländer, Pia Potthoff, Sophia Hadzibegovic, Sara Lena, Alessia Keller, Ulrich Landmesser, Ulf Schuster, Andreas Anker, Markus S. Hasenfuß, Gerd von Haehling, Stephan |
author_facet | Evertz, Ruben Gödde, Katharina Diehl, Christine Valentova, Miroslava Garfias‐Veitl, Tania Braulke, Friederike Wulf, Gerald G. Overbeck, Tobias R. Bleckmann, Annalen König, Alexander O. Weinländer, Pia Potthoff, Sophia Hadzibegovic, Sara Lena, Alessia Keller, Ulrich Landmesser, Ulf Schuster, Andreas Anker, Markus S. Hasenfuß, Gerd von Haehling, Stephan |
author_sort | Evertz, Ruben |
collection | PubMed |
description | AIMS: Maintaining quality of life (QoL) in patients with cancer has gathered significant interest, but little is known about its major determinants. We sought to identify determinants of QoL in patients undergoing cancer treatment as well as in treatment‐naïve patients about to commence such therapy. METHODS AND RESULTS: QoL was assessed in 283 patients with cancer using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 questionnaire. All patients underwent a battery of tests including physical examination, resting electrocardiogram, hand grip strength, and biochemistry assessment. Using multivariable logistic regression, we found that age [odds ratio (OR) 0.954, 95% confidence interval (CI) 0.916–0.994], resting heart rate (OR 1.036, 95% CI 1.004–1.068), hand grip strength (OR 0.932, 95% CI 0.878–0.990), and the presence of cachexia (OR 4.334, 95% CI 1.767–10.631) and dyspnoea (OR 3.725, 95% CI 1.540–9.010; all P < 0.05) remained independently predictive of reduced QoL. CONCLUSIONS: Therefore, it may be reasonable to address circumstances that are affecting muscle mass, body weight, and heart rate to maintaining QoL; however, prospective studies to test these endpoints are required. |
format | Online Article Text |
id | pubmed-9871717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98717172023-01-27 Cardiovascular and metabolic determinants of quality of life in patients with cancer Evertz, Ruben Gödde, Katharina Diehl, Christine Valentova, Miroslava Garfias‐Veitl, Tania Braulke, Friederike Wulf, Gerald G. Overbeck, Tobias R. Bleckmann, Annalen König, Alexander O. Weinländer, Pia Potthoff, Sophia Hadzibegovic, Sara Lena, Alessia Keller, Ulrich Landmesser, Ulf Schuster, Andreas Anker, Markus S. Hasenfuß, Gerd von Haehling, Stephan ESC Heart Fail Original Articles AIMS: Maintaining quality of life (QoL) in patients with cancer has gathered significant interest, but little is known about its major determinants. We sought to identify determinants of QoL in patients undergoing cancer treatment as well as in treatment‐naïve patients about to commence such therapy. METHODS AND RESULTS: QoL was assessed in 283 patients with cancer using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 questionnaire. All patients underwent a battery of tests including physical examination, resting electrocardiogram, hand grip strength, and biochemistry assessment. Using multivariable logistic regression, we found that age [odds ratio (OR) 0.954, 95% confidence interval (CI) 0.916–0.994], resting heart rate (OR 1.036, 95% CI 1.004–1.068), hand grip strength (OR 0.932, 95% CI 0.878–0.990), and the presence of cachexia (OR 4.334, 95% CI 1.767–10.631) and dyspnoea (OR 3.725, 95% CI 1.540–9.010; all P < 0.05) remained independently predictive of reduced QoL. CONCLUSIONS: Therefore, it may be reasonable to address circumstances that are affecting muscle mass, body weight, and heart rate to maintaining QoL; however, prospective studies to test these endpoints are required. John Wiley and Sons Inc. 2022-09-30 /pmc/articles/PMC9871717/ /pubmed/36178215 http://dx.doi.org/10.1002/ehf2.14175 Text en © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Evertz, Ruben Gödde, Katharina Diehl, Christine Valentova, Miroslava Garfias‐Veitl, Tania Braulke, Friederike Wulf, Gerald G. Overbeck, Tobias R. Bleckmann, Annalen König, Alexander O. Weinländer, Pia Potthoff, Sophia Hadzibegovic, Sara Lena, Alessia Keller, Ulrich Landmesser, Ulf Schuster, Andreas Anker, Markus S. Hasenfuß, Gerd von Haehling, Stephan Cardiovascular and metabolic determinants of quality of life in patients with cancer |
title | Cardiovascular and metabolic determinants of quality of life in patients with cancer |
title_full | Cardiovascular and metabolic determinants of quality of life in patients with cancer |
title_fullStr | Cardiovascular and metabolic determinants of quality of life in patients with cancer |
title_full_unstemmed | Cardiovascular and metabolic determinants of quality of life in patients with cancer |
title_short | Cardiovascular and metabolic determinants of quality of life in patients with cancer |
title_sort | cardiovascular and metabolic determinants of quality of life in patients with cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871717/ https://www.ncbi.nlm.nih.gov/pubmed/36178215 http://dx.doi.org/10.1002/ehf2.14175 |
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