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Modelling PIP4K2A inhibitory activity of 1,7-naphthyridine analogues using machine learning and molecular docking studies

PIP4K2A is a type II lipid kinase that catalyzed the rate-limiting step of the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol 4,5-bisphosphate (PI4,5P2). PIP4K2A has been intricately linked to the inhibition of various types of tumors via reactive oxygen species-medi...

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Detalles Bibliográficos
Autores principales:	Ibrahim, Muktar Musa, Uzairu, Adamu, Ibrahim, Muhammad Tukur, Umar, Abdullahi Bello
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871732/ https://www.ncbi.nlm.nih.gov/pubmed/36756602 http://dx.doi.org/10.1039/d2ra07382j

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