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Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria...

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Detalles Bibliográficos
Autores principales: Han, Jicheng, Zhu, Xiangyu, Gao, Zihan, Xiao, Yan, Zhang, Jinxin, Wang, Peng, Fang, Jinbo, Li, Yiquan, Zhu, Yilong, Li, Yue, Jin, Ningyi, Lu, Huijun, Lin, Dazhuan, Liu, Wenshen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871751/
https://www.ncbi.nlm.nih.gov/pubmed/36704555
http://dx.doi.org/10.3389/fmicb.2022.1067725
Descripción
Sumario:Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.