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Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
INTRODUCTION: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871772/ https://www.ncbi.nlm.nih.gov/pubmed/36705622 http://dx.doi.org/10.3389/fnagi.2022.971220 |
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author | Perus, Lisa Mangin, Jean-François Deverdun, Jérémy Gutierrez, Laure-Anne Gourieux, Emmanuelle Fischer, Clara Van Dokkum, Liesjet E. H. Manesco, Clara Busto, Germain Guyonnet, Sophie Vellas, Bruno Gabelle, Audrey Le Bars, Emmanuelle |
author_facet | Perus, Lisa Mangin, Jean-François Deverdun, Jérémy Gutierrez, Laure-Anne Gourieux, Emmanuelle Fischer, Clara Van Dokkum, Liesjet E. H. Manesco, Clara Busto, Germain Guyonnet, Sophie Vellas, Bruno Gabelle, Audrey Le Bars, Emmanuelle |
author_sort | Perus, Lisa |
collection | PubMed |
description | INTRODUCTION: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC). METHODS: To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints. RESULTS: No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden. DISCUSSION: These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions. |
format | Online Article Text |
id | pubmed-9871772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98717722023-01-25 Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study Perus, Lisa Mangin, Jean-François Deverdun, Jérémy Gutierrez, Laure-Anne Gourieux, Emmanuelle Fischer, Clara Van Dokkum, Liesjet E. H. Manesco, Clara Busto, Germain Guyonnet, Sophie Vellas, Bruno Gabelle, Audrey Le Bars, Emmanuelle Front Aging Neurosci Aging Neuroscience INTRODUCTION: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC). METHODS: To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints. RESULTS: No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden. DISCUSSION: These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9871772/ /pubmed/36705622 http://dx.doi.org/10.3389/fnagi.2022.971220 Text en Copyright © 2023 Perus, Mangin, Deverdun, Gutierrez, Gourieux, Fischer, Van Dokkum, Manesco, Busto, Guyonnet, Vellas, Gabelle, Le Bars and the MAPT/DSA group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Perus, Lisa Mangin, Jean-François Deverdun, Jérémy Gutierrez, Laure-Anne Gourieux, Emmanuelle Fischer, Clara Van Dokkum, Liesjet E. H. Manesco, Clara Busto, Germain Guyonnet, Sophie Vellas, Bruno Gabelle, Audrey Le Bars, Emmanuelle Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study |
title | Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study |
title_full | Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study |
title_fullStr | Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study |
title_full_unstemmed | Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study |
title_short | Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study |
title_sort | impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: subset from the montpellier center of the ancillary mapt-mri study |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871772/ https://www.ncbi.nlm.nih.gov/pubmed/36705622 http://dx.doi.org/10.3389/fnagi.2022.971220 |
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