Cargando…

Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study

INTRODUCTION: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood...

Descripción completa

Detalles Bibliográficos
Autores principales: Perus, Lisa, Mangin, Jean-François, Deverdun, Jérémy, Gutierrez, Laure-Anne, Gourieux, Emmanuelle, Fischer, Clara, Van Dokkum, Liesjet E. H., Manesco, Clara, Busto, Germain, Guyonnet, Sophie, Vellas, Bruno, Gabelle, Audrey, Le Bars, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871772/
https://www.ncbi.nlm.nih.gov/pubmed/36705622
http://dx.doi.org/10.3389/fnagi.2022.971220
_version_ 1784877254697811968
author Perus, Lisa
Mangin, Jean-François
Deverdun, Jérémy
Gutierrez, Laure-Anne
Gourieux, Emmanuelle
Fischer, Clara
Van Dokkum, Liesjet E. H.
Manesco, Clara
Busto, Germain
Guyonnet, Sophie
Vellas, Bruno
Gabelle, Audrey
Le Bars, Emmanuelle
author_facet Perus, Lisa
Mangin, Jean-François
Deverdun, Jérémy
Gutierrez, Laure-Anne
Gourieux, Emmanuelle
Fischer, Clara
Van Dokkum, Liesjet E. H.
Manesco, Clara
Busto, Germain
Guyonnet, Sophie
Vellas, Bruno
Gabelle, Audrey
Le Bars, Emmanuelle
author_sort Perus, Lisa
collection PubMed
description INTRODUCTION: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC). METHODS: To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints. RESULTS: No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden. DISCUSSION: These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions.
format Online
Article
Text
id pubmed-9871772
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98717722023-01-25 Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study Perus, Lisa Mangin, Jean-François Deverdun, Jérémy Gutierrez, Laure-Anne Gourieux, Emmanuelle Fischer, Clara Van Dokkum, Liesjet E. H. Manesco, Clara Busto, Germain Guyonnet, Sophie Vellas, Bruno Gabelle, Audrey Le Bars, Emmanuelle Front Aging Neurosci Aging Neuroscience INTRODUCTION: The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC). METHODS: To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints. RESULTS: No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden. DISCUSSION: These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9871772/ /pubmed/36705622 http://dx.doi.org/10.3389/fnagi.2022.971220 Text en Copyright © 2023 Perus, Mangin, Deverdun, Gutierrez, Gourieux, Fischer, Van Dokkum, Manesco, Busto, Guyonnet, Vellas, Gabelle, Le Bars and the MAPT/DSA group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Perus, Lisa
Mangin, Jean-François
Deverdun, Jérémy
Gutierrez, Laure-Anne
Gourieux, Emmanuelle
Fischer, Clara
Van Dokkum, Liesjet E. H.
Manesco, Clara
Busto, Germain
Guyonnet, Sophie
Vellas, Bruno
Gabelle, Audrey
Le Bars, Emmanuelle
Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
title Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
title_full Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
title_fullStr Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
title_full_unstemmed Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
title_short Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
title_sort impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: subset from the montpellier center of the ancillary mapt-mri study
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871772/
https://www.ncbi.nlm.nih.gov/pubmed/36705622
http://dx.doi.org/10.3389/fnagi.2022.971220
work_keys_str_mv AT peruslisa impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT manginjeanfrancois impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT deverdunjeremy impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT gutierrezlaureanne impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT gourieuxemmanuelle impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT fischerclara impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT vandokkumliesjeteh impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT manescoclara impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT bustogermain impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT guyonnetsophie impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT vellasbruno impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT gabelleaudrey impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT lebarsemmanuelle impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy
AT impactofmultidomainpreventivestrategiesonfunctionalbrainconnectivityinolderadultswithcognitivecomplaintsubsetfromthemontpelliercenteroftheancillarymaptmristudy