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Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report
We report a case of a 66-year-old male diagnosed with refractory to oral corticosteroids eosinophilic cystitis (EoC). Hematuria was the first and only sign of the disease that was otherwise asymptomatic, and the only abnormal lab finding he had was peripheral eosinophilia (700 cells/μl). Due to card...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871778/ https://www.ncbi.nlm.nih.gov/pubmed/36704755 http://dx.doi.org/10.3389/falgy.2022.1055129 |
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author | Konstantinou, George N. Voukelatou, Vasiliki |
author_facet | Konstantinou, George N. Voukelatou, Vasiliki |
author_sort | Konstantinou, George N. |
collection | PubMed |
description | We report a case of a 66-year-old male diagnosed with refractory to oral corticosteroids eosinophilic cystitis (EoC). Hematuria was the first and only sign of the disease that was otherwise asymptomatic, and the only abnormal lab finding he had was peripheral eosinophilia (700 cells/μl). Due to cardiovascular issues, an invasive surgical procedure was declined. As an alternative, benralizumab, an anti-IL-5Rα monoclonal antibody with anti-eosinophilic properties, was administered. The patient responded rapidly with clinical and histological complete remission of the EoC four months after benralizumab started. He continued benralizumab 30 mg Q4-weeks for 12 months without experiencing any side effects. Six months after the last dose, he is completely healthy with no peripheral eosinophilia. EoC is a rare condition with no standardized treatment. Those with corticosteroid-refractory EoC are eligible for surgery. Benralizumab has an excellent safety profile; therefore, it should be considered before deciding on invasive surgical procedures in selected, refractory to non-specific treatment cases, especially with EoC of unclear etiology. It is unclear if benralizumab may immunomodulate the unknown underlying mechanisms of EoC, considering that EoC did not relapse after benralizumab was deemed eliminated. Further studies are needed to investigate this possibility. |
format | Online Article Text |
id | pubmed-9871778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98717782023-01-25 Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report Konstantinou, George N. Voukelatou, Vasiliki Front Allergy Allergy We report a case of a 66-year-old male diagnosed with refractory to oral corticosteroids eosinophilic cystitis (EoC). Hematuria was the first and only sign of the disease that was otherwise asymptomatic, and the only abnormal lab finding he had was peripheral eosinophilia (700 cells/μl). Due to cardiovascular issues, an invasive surgical procedure was declined. As an alternative, benralizumab, an anti-IL-5Rα monoclonal antibody with anti-eosinophilic properties, was administered. The patient responded rapidly with clinical and histological complete remission of the EoC four months after benralizumab started. He continued benralizumab 30 mg Q4-weeks for 12 months without experiencing any side effects. Six months after the last dose, he is completely healthy with no peripheral eosinophilia. EoC is a rare condition with no standardized treatment. Those with corticosteroid-refractory EoC are eligible for surgery. Benralizumab has an excellent safety profile; therefore, it should be considered before deciding on invasive surgical procedures in selected, refractory to non-specific treatment cases, especially with EoC of unclear etiology. It is unclear if benralizumab may immunomodulate the unknown underlying mechanisms of EoC, considering that EoC did not relapse after benralizumab was deemed eliminated. Further studies are needed to investigate this possibility. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9871778/ /pubmed/36704755 http://dx.doi.org/10.3389/falgy.2022.1055129 Text en © 2023 Konstantinou and Voukelatou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Allergy Konstantinou, George N. Voukelatou, Vasiliki Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report |
title | Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report |
title_full | Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report |
title_fullStr | Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report |
title_full_unstemmed | Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report |
title_short | Eosinophilic cystitis refractory to steroids successfully treated with benralizumab: A case report |
title_sort | eosinophilic cystitis refractory to steroids successfully treated with benralizumab: a case report |
topic | Allergy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871778/ https://www.ncbi.nlm.nih.gov/pubmed/36704755 http://dx.doi.org/10.3389/falgy.2022.1055129 |
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