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MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework

Staphylococcus aureus is recognized as commensal as well as opportunistic pathogen of humans and animals. Methicillin resistant strain of S. aureus (MRSA) has emerged as a major pathogen in hospitals, community and veterinary settings that compromises the public health and livestock production. MRSA...

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Autores principales: Shoaib, Muhammad, Aqib, Amjad Islam, Muzammil, Iqra, Majeed, Noreen, Bhutta, Zeeshan Ahmad, Kulyar, Muhammad Fakhar-e-Alam, Fatima, Mahreen, Zaheer, C-Neen Fatima, Muneer, Afshan, Murtaza, Maheen, Kashif, Muhammad, Shafqat, Furqan, Pu, Wanxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871788/
https://www.ncbi.nlm.nih.gov/pubmed/36704547
http://dx.doi.org/10.3389/fmicb.2022.1067284
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author Shoaib, Muhammad
Aqib, Amjad Islam
Muzammil, Iqra
Majeed, Noreen
Bhutta, Zeeshan Ahmad
Kulyar, Muhammad Fakhar-e-Alam
Fatima, Mahreen
Zaheer, C-Neen Fatima
Muneer, Afshan
Murtaza, Maheen
Kashif, Muhammad
Shafqat, Furqan
Pu, Wanxia
author_facet Shoaib, Muhammad
Aqib, Amjad Islam
Muzammil, Iqra
Majeed, Noreen
Bhutta, Zeeshan Ahmad
Kulyar, Muhammad Fakhar-e-Alam
Fatima, Mahreen
Zaheer, C-Neen Fatima
Muneer, Afshan
Murtaza, Maheen
Kashif, Muhammad
Shafqat, Furqan
Pu, Wanxia
author_sort Shoaib, Muhammad
collection PubMed
description Staphylococcus aureus is recognized as commensal as well as opportunistic pathogen of humans and animals. Methicillin resistant strain of S. aureus (MRSA) has emerged as a major pathogen in hospitals, community and veterinary settings that compromises the public health and livestock production. MRSA basically emerged from MSSA after acquiring SCCmec element through gene transfer containing mecA gene responsible for encoding PBP-2α. This protein renders the MRSA resistant to most of the β-lactam antibiotics. Due to the continuous increasing prevalence and transmission of MRSA in hospitals, community and veterinary settings posing a major threat to public health. Furthermore, high pathogenicity of MRSA due to a number of virulence factors produced by S. aureus along with antibiotic resistance help to breach the immunity of host and responsible for causing severe infections in humans and animals. The clinical manifestations of MRSA consist of skin and soft tissues infection to bacteremia, septicemia, toxic shock, and scalded skin syndrome. Moreover, due to the increasing resistance of MRSA to number of antibiotics, there is need to approach alternatives ways to overcome economic as well as human losses. This review is going to discuss various aspects of MRSA starting from emergence, transmission, epidemiology, pathophysiology, disease patterns in hosts, novel treatment, and control strategies.
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spelling pubmed-98717882023-01-25 MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework Shoaib, Muhammad Aqib, Amjad Islam Muzammil, Iqra Majeed, Noreen Bhutta, Zeeshan Ahmad Kulyar, Muhammad Fakhar-e-Alam Fatima, Mahreen Zaheer, C-Neen Fatima Muneer, Afshan Murtaza, Maheen Kashif, Muhammad Shafqat, Furqan Pu, Wanxia Front Microbiol Microbiology Staphylococcus aureus is recognized as commensal as well as opportunistic pathogen of humans and animals. Methicillin resistant strain of S. aureus (MRSA) has emerged as a major pathogen in hospitals, community and veterinary settings that compromises the public health and livestock production. MRSA basically emerged from MSSA after acquiring SCCmec element through gene transfer containing mecA gene responsible for encoding PBP-2α. This protein renders the MRSA resistant to most of the β-lactam antibiotics. Due to the continuous increasing prevalence and transmission of MRSA in hospitals, community and veterinary settings posing a major threat to public health. Furthermore, high pathogenicity of MRSA due to a number of virulence factors produced by S. aureus along with antibiotic resistance help to breach the immunity of host and responsible for causing severe infections in humans and animals. The clinical manifestations of MRSA consist of skin and soft tissues infection to bacteremia, septicemia, toxic shock, and scalded skin syndrome. Moreover, due to the increasing resistance of MRSA to number of antibiotics, there is need to approach alternatives ways to overcome economic as well as human losses. This review is going to discuss various aspects of MRSA starting from emergence, transmission, epidemiology, pathophysiology, disease patterns in hosts, novel treatment, and control strategies. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9871788/ /pubmed/36704547 http://dx.doi.org/10.3389/fmicb.2022.1067284 Text en Copyright © 2023 Shoaib, Aqib, Muzammil, Majeed, Bhutta, Kulyar, Fatima, Zaheer, Muneer, Murtaza, Kashif, Shafqat and Pu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Shoaib, Muhammad
Aqib, Amjad Islam
Muzammil, Iqra
Majeed, Noreen
Bhutta, Zeeshan Ahmad
Kulyar, Muhammad Fakhar-e-Alam
Fatima, Mahreen
Zaheer, C-Neen Fatima
Muneer, Afshan
Murtaza, Maheen
Kashif, Muhammad
Shafqat, Furqan
Pu, Wanxia
MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
title MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
title_full MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
title_fullStr MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
title_full_unstemmed MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
title_short MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
title_sort mrsa compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871788/
https://www.ncbi.nlm.nih.gov/pubmed/36704547
http://dx.doi.org/10.3389/fmicb.2022.1067284
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