Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice

INTRODUCTION: Alzheimer’s disease (AD) is the most frequent cause of dementia and still lacks effective therapy. Clinical signs of AD include low levels of endogenous melanocortins (MCs) and previous studies have shown that treatment with MC analogs induces neuroprotection in the early stages of AD....

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Detalles Bibliográficos
Autores principales: Daini, Eleonora, Vandini, Eleonora, Bodria, Martina, Liao, Wenjie, Baraldi, Carlo, Secco, Valentina, Ottani, Alessandra, Zoli, Michele, Giuliani, Daniela, Vilella, Antonietta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871936/
https://www.ncbi.nlm.nih.gov/pubmed/36703981
http://dx.doi.org/10.3389/fimmu.2022.1082036

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