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Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018

INTRODUCTION: The present study aimed to examine the impact of age at menopause on the type 2 diabetes mellitus (T2DM) risk in postmenopausal women. MATERIAL AND METHODS: We included 4,968 postmenopausal women from the National Health and Nutrition Examination Survey 2011–2018. Age at menopause was...

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Autores principales: Xing, Zailing, Kirby, Russell S., Alman, Amy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871996/
https://www.ncbi.nlm.nih.gov/pubmed/36704768
http://dx.doi.org/10.5114/pm.2022.123514
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author Xing, Zailing
Kirby, Russell S.
Alman, Amy C.
author_facet Xing, Zailing
Kirby, Russell S.
Alman, Amy C.
author_sort Xing, Zailing
collection PubMed
description INTRODUCTION: The present study aimed to examine the impact of age at menopause on the type 2 diabetes mellitus (T2DM) risk in postmenopausal women. MATERIAL AND METHODS: We included 4,968 postmenopausal women from the National Health and Nutrition Examination Survey 2011–2018. Age at menopause was measured by single year and categorically (< 40 years, 40–44 years, 45–54 years, 55 years and above). The outcome variable T2DM was measured with self-report and fasting blood glucose level. We performed logistic regression to estimate the odds ratio (OR) (95% confidence interval [CI]). Linear regression was used to examine the correlation between age at menopause and age at T2DM. RESULTS: Of the 4,968 postmenopausal women, 796 (16.0%) had T2DM after menopause. The mean age at menopause was 44.2 years. The mean age at T2DM was 57.2 years. Adjusting for potential confounders, the ORs for the association between age at menopause of < 40 years, 40–44 years and ≥ 55 years and T2DM were 1.97 (95% CI: 1.47–2.63), 1.27 (95% CI: 0.90–1.79) and 0.98 (95% CI: 0.66–1.45), respectively, compared to women having menopause at age 45 to 54 years. Each increase by 1 year in age at menopause was associated with a 3% reduction in the prevalence of T2DM (95% CI: 2–5). Age at menopause was significantly correlated with age at T2DM. Each 1-year increase in age at menopause might lead to a decrease of 0.39 years in age at T2DM. CONCLUSIONS: Premature menopause was associated with increased T2DM risk in women. The earlier menopause occurs, the younger is the age at which T2DM may occur.
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spelling pubmed-98719962023-01-25 Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018 Xing, Zailing Kirby, Russell S. Alman, Amy C. Prz Menopauzalny Original Paper INTRODUCTION: The present study aimed to examine the impact of age at menopause on the type 2 diabetes mellitus (T2DM) risk in postmenopausal women. MATERIAL AND METHODS: We included 4,968 postmenopausal women from the National Health and Nutrition Examination Survey 2011–2018. Age at menopause was measured by single year and categorically (< 40 years, 40–44 years, 45–54 years, 55 years and above). The outcome variable T2DM was measured with self-report and fasting blood glucose level. We performed logistic regression to estimate the odds ratio (OR) (95% confidence interval [CI]). Linear regression was used to examine the correlation between age at menopause and age at T2DM. RESULTS: Of the 4,968 postmenopausal women, 796 (16.0%) had T2DM after menopause. The mean age at menopause was 44.2 years. The mean age at T2DM was 57.2 years. Adjusting for potential confounders, the ORs for the association between age at menopause of < 40 years, 40–44 years and ≥ 55 years and T2DM were 1.97 (95% CI: 1.47–2.63), 1.27 (95% CI: 0.90–1.79) and 0.98 (95% CI: 0.66–1.45), respectively, compared to women having menopause at age 45 to 54 years. Each increase by 1 year in age at menopause was associated with a 3% reduction in the prevalence of T2DM (95% CI: 2–5). Age at menopause was significantly correlated with age at T2DM. Each 1-year increase in age at menopause might lead to a decrease of 0.39 years in age at T2DM. CONCLUSIONS: Premature menopause was associated with increased T2DM risk in women. The earlier menopause occurs, the younger is the age at which T2DM may occur. Termedia Publishing House 2022-12-30 2022-12 /pmc/articles/PMC9871996/ /pubmed/36704768 http://dx.doi.org/10.5114/pm.2022.123514 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Xing, Zailing
Kirby, Russell S.
Alman, Amy C.
Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018
title Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018
title_full Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018
title_fullStr Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018
title_full_unstemmed Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018
title_short Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018
title_sort association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the united states: national health and nutrition examination survey 2011–2018
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871996/
https://www.ncbi.nlm.nih.gov/pubmed/36704768
http://dx.doi.org/10.5114/pm.2022.123514
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