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Personalized transcranial alternating current stimulation improves sleep quality: Initial findings

Insufficient sleep is a major health issue. Inadequate sleep is associated with an array of poor health outcomes, including cardiovascular disease, diabetes, obesity, certain forms of cancer, Alzheimer’s disease, depression, anxiety, and suicidality. Given concerns with typical sedative hypnotic dru...

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Autores principales: Ayanampudi, V., Kumar, V., Krishnan, A., Walker, M. P., Ivry, R. B., Knight, R. T., Gurumoorthy, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872012/
https://www.ncbi.nlm.nih.gov/pubmed/36704097
http://dx.doi.org/10.3389/fnhum.2022.1066453
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author Ayanampudi, V.
Kumar, V.
Krishnan, A.
Walker, M. P.
Ivry, R. B.
Knight, R. T.
Gurumoorthy, R.
author_facet Ayanampudi, V.
Kumar, V.
Krishnan, A.
Walker, M. P.
Ivry, R. B.
Knight, R. T.
Gurumoorthy, R.
author_sort Ayanampudi, V.
collection PubMed
description Insufficient sleep is a major health issue. Inadequate sleep is associated with an array of poor health outcomes, including cardiovascular disease, diabetes, obesity, certain forms of cancer, Alzheimer’s disease, depression, anxiety, and suicidality. Given concerns with typical sedative hypnotic drugs for treating sleep difficulties, there is a compelling need for alternative interventions. Here, we report results of a non-invasive electrical brain stimulation approach to optimizing sleep involving transcranial alternating current stimulation (tACS). A total of 25 participants (mean age: 46.3, S.D. ± 12.4, 15 females) were recruited for a null-stimulation controlled (Control condition), within subjects, randomized crossed design, that included two variants of an active condition involving 15 min pre-sleep tACS stimulation. To evaluate the impact on sleep quality, the two active tACS stimulation conditions were designed to modulate sleep-dependent neural activity in the theta/alpha frequency bands, with both stimulation types applied to all subjects in separate sessions. The first tACS condition used a fixed stimulation pattern across all participants, a pattern composed of stimulation at 5 and 10 Hz. The second tACS condition used a personalized stimulation approach with the stimulation frequencies determined by each individual’s peak EEG frequencies in the 4–6 Hz and 9–11 Hz bands. Personalized tACS stimulation increased sleep quantity (duration) by 22 min compared to a Control condition (p = 0.04), and 19 min compared to Fixed tACS stimulation (p = 0.03). Fixed stimulation did not significantly increase sleep duration compared to Control (mean: 3 min; p = 0.75). For sleep onset, the Personalized tACS stimulation resulted in reducing the onset by 28% compared to the Fixed tACS stimulation (6 min faster, p = 0.02). For a Poor Sleep sub-group (n = 13) categorized with Clinical Insomnia and a high insomnia severity, Personalized tACS stimulation improved sleep duration by 33 min compared to Fixed stimulation (p = 0.02), and 30 min compared to Control condition (p < 0.1). Together, these results suggest that Personalized stimulation improves sleep quantity and time taken to fall asleep relative to Control and Fixed stimulation providing motivation for larger-scale trials for Personalized tACS as a sleep therapeutic, including for those with insomnia.
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spelling pubmed-98720122023-01-25 Personalized transcranial alternating current stimulation improves sleep quality: Initial findings Ayanampudi, V. Kumar, V. Krishnan, A. Walker, M. P. Ivry, R. B. Knight, R. T. Gurumoorthy, R. Front Hum Neurosci Neuroscience Insufficient sleep is a major health issue. Inadequate sleep is associated with an array of poor health outcomes, including cardiovascular disease, diabetes, obesity, certain forms of cancer, Alzheimer’s disease, depression, anxiety, and suicidality. Given concerns with typical sedative hypnotic drugs for treating sleep difficulties, there is a compelling need for alternative interventions. Here, we report results of a non-invasive electrical brain stimulation approach to optimizing sleep involving transcranial alternating current stimulation (tACS). A total of 25 participants (mean age: 46.3, S.D. ± 12.4, 15 females) were recruited for a null-stimulation controlled (Control condition), within subjects, randomized crossed design, that included two variants of an active condition involving 15 min pre-sleep tACS stimulation. To evaluate the impact on sleep quality, the two active tACS stimulation conditions were designed to modulate sleep-dependent neural activity in the theta/alpha frequency bands, with both stimulation types applied to all subjects in separate sessions. The first tACS condition used a fixed stimulation pattern across all participants, a pattern composed of stimulation at 5 and 10 Hz. The second tACS condition used a personalized stimulation approach with the stimulation frequencies determined by each individual’s peak EEG frequencies in the 4–6 Hz and 9–11 Hz bands. Personalized tACS stimulation increased sleep quantity (duration) by 22 min compared to a Control condition (p = 0.04), and 19 min compared to Fixed tACS stimulation (p = 0.03). Fixed stimulation did not significantly increase sleep duration compared to Control (mean: 3 min; p = 0.75). For sleep onset, the Personalized tACS stimulation resulted in reducing the onset by 28% compared to the Fixed tACS stimulation (6 min faster, p = 0.02). For a Poor Sleep sub-group (n = 13) categorized with Clinical Insomnia and a high insomnia severity, Personalized tACS stimulation improved sleep duration by 33 min compared to Fixed stimulation (p = 0.02), and 30 min compared to Control condition (p < 0.1). Together, these results suggest that Personalized stimulation improves sleep quantity and time taken to fall asleep relative to Control and Fixed stimulation providing motivation for larger-scale trials for Personalized tACS as a sleep therapeutic, including for those with insomnia. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9872012/ /pubmed/36704097 http://dx.doi.org/10.3389/fnhum.2022.1066453 Text en Copyright © 2023 Ayanampudi, Kumar, Krishnan, Walker, Ivry, Knight and Gurumoorthy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ayanampudi, V.
Kumar, V.
Krishnan, A.
Walker, M. P.
Ivry, R. B.
Knight, R. T.
Gurumoorthy, R.
Personalized transcranial alternating current stimulation improves sleep quality: Initial findings
title Personalized transcranial alternating current stimulation improves sleep quality: Initial findings
title_full Personalized transcranial alternating current stimulation improves sleep quality: Initial findings
title_fullStr Personalized transcranial alternating current stimulation improves sleep quality: Initial findings
title_full_unstemmed Personalized transcranial alternating current stimulation improves sleep quality: Initial findings
title_short Personalized transcranial alternating current stimulation improves sleep quality: Initial findings
title_sort personalized transcranial alternating current stimulation improves sleep quality: initial findings
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872012/
https://www.ncbi.nlm.nih.gov/pubmed/36704097
http://dx.doi.org/10.3389/fnhum.2022.1066453
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