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Potassium channels: Novel targets for tumor diagnosis and chemoresistance

In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells. The expression and dysfunction of potassium channels are closely related to tumor progression. Potassiu...

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Autores principales: Li, Meizeng, Tian, Peijie, Zhao, Qing, Ma, Xialin, Zhang, Yunxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872028/
https://www.ncbi.nlm.nih.gov/pubmed/36703789
http://dx.doi.org/10.3389/fonc.2022.1074469
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author Li, Meizeng
Tian, Peijie
Zhao, Qing
Ma, Xialin
Zhang, Yunxiang
author_facet Li, Meizeng
Tian, Peijie
Zhao, Qing
Ma, Xialin
Zhang, Yunxiang
author_sort Li, Meizeng
collection PubMed
description In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells. The expression and dysfunction of potassium channels are closely related to tumor progression. Potassium channel blockers or activators present antitumor effects by directly inhibiting tumor growth or enhancing the potency of classical antitumor agents in combination therapy. This article reviews the mechanisms by which potassium channels contribute to tumor development in various tumors in recent years, introduces the potential of potassium channels as diagnostic targets and therapeutic means for tumors, and provides further ideas for the proper individualized treatment of tumors.
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spelling pubmed-98720282023-01-25 Potassium channels: Novel targets for tumor diagnosis and chemoresistance Li, Meizeng Tian, Peijie Zhao, Qing Ma, Xialin Zhang, Yunxiang Front Oncol Oncology In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells. The expression and dysfunction of potassium channels are closely related to tumor progression. Potassium channel blockers or activators present antitumor effects by directly inhibiting tumor growth or enhancing the potency of classical antitumor agents in combination therapy. This article reviews the mechanisms by which potassium channels contribute to tumor development in various tumors in recent years, introduces the potential of potassium channels as diagnostic targets and therapeutic means for tumors, and provides further ideas for the proper individualized treatment of tumors. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9872028/ /pubmed/36703789 http://dx.doi.org/10.3389/fonc.2022.1074469 Text en Copyright © 2023 Li, Tian, Zhao, Ma and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Meizeng
Tian, Peijie
Zhao, Qing
Ma, Xialin
Zhang, Yunxiang
Potassium channels: Novel targets for tumor diagnosis and chemoresistance
title Potassium channels: Novel targets for tumor diagnosis and chemoresistance
title_full Potassium channels: Novel targets for tumor diagnosis and chemoresistance
title_fullStr Potassium channels: Novel targets for tumor diagnosis and chemoresistance
title_full_unstemmed Potassium channels: Novel targets for tumor diagnosis and chemoresistance
title_short Potassium channels: Novel targets for tumor diagnosis and chemoresistance
title_sort potassium channels: novel targets for tumor diagnosis and chemoresistance
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872028/
https://www.ncbi.nlm.nih.gov/pubmed/36703789
http://dx.doi.org/10.3389/fonc.2022.1074469
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