Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function

[Image: see text] Methylglyoxal (MGO), a reactive metabolite byproduct of glucose metabolism, is known to form a variety of posttranslational modifications (PTMs) on nucleophilic amino acids. For example, cysteine, the most nucleophilic proteinogenic amino acid, forms reversible hemithioacetal and s...

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Detalles Bibliográficos
Autores principales: Coukos, John S., Lee, Chris W., Pillai, Kavya S., Liu, Kimberly J., Moellering, Raymond E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872086/
https://www.ncbi.nlm.nih.gov/pubmed/36562291
http://dx.doi.org/10.1021/acschembio.2c00727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872086/
https://www.ncbi.nlm.nih.gov/pubmed/36562291
http://dx.doi.org/10.1021/acschembio.2c00727

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