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Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function
[Image: see text] Methylglyoxal (MGO), a reactive metabolite byproduct of glucose metabolism, is known to form a variety of posttranslational modifications (PTMs) on nucleophilic amino acids. For example, cysteine, the most nucleophilic proteinogenic amino acid, forms reversible hemithioacetal and s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872086/ https://www.ncbi.nlm.nih.gov/pubmed/36562291 http://dx.doi.org/10.1021/acschembio.2c00727 |