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Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation

OBJECTIVE: Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function. Here, we investigated the...

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Detalles Bibliográficos
Autores principales:	Martínez-Sánchez, Luz del Carmen, Ngo, Phuong Anh, Pradhan, Rashmita, Becker, Lukas-Sebastian, Boehringer, David, Soteriou, Despina, Kubankova, Marketa, Schweitzer, Christine, Koch, Tatyana, Thonn, Veronika, Erkert, Lena, Stolzer, Iris, Günther, Claudia, Becker, Christoph, Weigmann, Benno, Klewer, Monika, Daniel, Christoph, Amann, Kerstin, Tenzer, Stefan, Atreya, Raja, Bergo, Martin, Brakebusch, Cord, Watson, Alastair J M, Guck, Jochen, Fabry, Ben, Atreya, Imke, Neurath, Markus F, López-Posadas, Rocío
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Inflammatory Bowel Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872254/ https://www.ncbi.nlm.nih.gov/pubmed/35241625 http://dx.doi.org/10.1136/gutjnl-2021-325520

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