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Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia

BACKGROUND: Gilteritinib is the only drug approved as monotherapy for acute myeloid leukemia (AML) patients harboring FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation throughout the world. However, drug resistance inevitably develops in clinical. Sitravatinib is a multi-kin...

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Detalles Bibliográficos
Autores principales:	Zhang, Yvyin, Wang, Peihong, Wang, Yang, Shen, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872318/ https://www.ncbi.nlm.nih.gov/pubmed/36691065 http://dx.doi.org/10.1186/s40364-022-00447-4

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