Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role in controlling learning, memory and synaptic plasticity. Since early-life inflammation has been reported to adversely affect...

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Detalles Bibliográficos
Autores principales: Rong, Jing, Yang, Yang, Liang, Min, Zhong, Haiquan, Li, Yingchun, Zhu, Yichao, Sha, Sha, Chen, Lei, Zhou, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872321/
https://www.ncbi.nlm.nih.gov/pubmed/36691035
http://dx.doi.org/10.1186/s12974-023-02697-x

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