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Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. First-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. Unfortunately, iatrogenic impulsive-compulsive behaviors (ICBs) can occur in up to 2...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Akadémiai Kiadó
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872544/ https://www.ncbi.nlm.nih.gov/pubmed/35960604 http://dx.doi.org/10.1556/2006.2022.00051 |
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author | Grall-Bronnec, Marie Victorri-Vigneau, Caroline Rouaud, Tiphaine Verholleman, Audrey Schreck, Benoit Leboucher, Juliette Thiabaud, Elsa Feuillet, Fanny Roy, Monica Hardouin, Jean-Benoit Guillou-Landreat, Morgane Derkinderen, Pascal Challet-Bouju, Gaëlle |
author_facet | Grall-Bronnec, Marie Victorri-Vigneau, Caroline Rouaud, Tiphaine Verholleman, Audrey Schreck, Benoit Leboucher, Juliette Thiabaud, Elsa Feuillet, Fanny Roy, Monica Hardouin, Jean-Benoit Guillou-Landreat, Morgane Derkinderen, Pascal Challet-Bouju, Gaëlle |
author_sort | Grall-Bronnec, Marie |
collection | PubMed |
description | BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. First-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. Unfortunately, iatrogenic impulsive-compulsive behaviors (ICBs) can occur in up to 20% of PD patients over the course of their illness. ICBs must be considered multifactorial disorders that reflect the interactions of the medication with an individual's vulnerability and the underlying neurobiology of PD. We aimed to explore the predictive genetic, psychopathological and neurological factors involved in the development of ICBs in PD patients by building a complete model of individual vulnerability. METHODS: The PARKADD study was a case/non-case study. A total of 225 patients were enrolled (“ICB” group, N = 75; “no ICB” group, N = 150), and 163 agreed to provide saliva samples for genetic analysis. Sociodemographic, neurological and psychiatric characteristics were assessed, and genotyping for the characterization of polymorphisms related to dopaminergic and opioid systems was performed. RESULTS: Factors associated with “ICBs” were younger age of PD onset, personal history of ICB prior to PD onset and higher scores on the urgency and sensation seeking facets of impulsivity. No gene variant was significantly associated, but the association with the opioid receptor mu 1 (OPRM1) rs1799971 polymorphism was close to significance. DISCUSSION AND CONCLUSIONS: The influence of gene-environment interactions probably exists, and additional studies are needed to decipher the possible role of the opioid system in the development of ICBs in PD patients. |
format | Online Article Text |
id | pubmed-9872544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Akadémiai Kiadó |
record_format | MEDLINE/PubMed |
spelling | pubmed-98725442023-02-01 Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability Grall-Bronnec, Marie Victorri-Vigneau, Caroline Rouaud, Tiphaine Verholleman, Audrey Schreck, Benoit Leboucher, Juliette Thiabaud, Elsa Feuillet, Fanny Roy, Monica Hardouin, Jean-Benoit Guillou-Landreat, Morgane Derkinderen, Pascal Challet-Bouju, Gaëlle J Behav Addict Article BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. First-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. Unfortunately, iatrogenic impulsive-compulsive behaviors (ICBs) can occur in up to 20% of PD patients over the course of their illness. ICBs must be considered multifactorial disorders that reflect the interactions of the medication with an individual's vulnerability and the underlying neurobiology of PD. We aimed to explore the predictive genetic, psychopathological and neurological factors involved in the development of ICBs in PD patients by building a complete model of individual vulnerability. METHODS: The PARKADD study was a case/non-case study. A total of 225 patients were enrolled (“ICB” group, N = 75; “no ICB” group, N = 150), and 163 agreed to provide saliva samples for genetic analysis. Sociodemographic, neurological and psychiatric characteristics were assessed, and genotyping for the characterization of polymorphisms related to dopaminergic and opioid systems was performed. RESULTS: Factors associated with “ICBs” were younger age of PD onset, personal history of ICB prior to PD onset and higher scores on the urgency and sensation seeking facets of impulsivity. No gene variant was significantly associated, but the association with the opioid receptor mu 1 (OPRM1) rs1799971 polymorphism was close to significance. DISCUSSION AND CONCLUSIONS: The influence of gene-environment interactions probably exists, and additional studies are needed to decipher the possible role of the opioid system in the development of ICBs in PD patients. Akadémiai Kiadó 2022-08-11 2022-09 /pmc/articles/PMC9872544/ /pubmed/35960604 http://dx.doi.org/10.1556/2006.2022.00051 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/ Open Access. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated. |
spellingShingle | Article Grall-Bronnec, Marie Victorri-Vigneau, Caroline Rouaud, Tiphaine Verholleman, Audrey Schreck, Benoit Leboucher, Juliette Thiabaud, Elsa Feuillet, Fanny Roy, Monica Hardouin, Jean-Benoit Guillou-Landreat, Morgane Derkinderen, Pascal Challet-Bouju, Gaëlle Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability |
title | Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability |
title_full | Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability |
title_fullStr | Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability |
title_full_unstemmed | Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability |
title_short | Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability |
title_sort | parkinson's disease and iatrogenic impulsive-compulsive behaviors: a case/non-case study to build a complete model of individual vulnerability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872544/ https://www.ncbi.nlm.nih.gov/pubmed/35960604 http://dx.doi.org/10.1556/2006.2022.00051 |
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