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Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability

BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. First-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. Unfortunately, iatrogenic impulsive-compulsive behaviors (ICBs) can occur in up to 2...

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Autores principales: Grall-Bronnec, Marie, Victorri-Vigneau, Caroline, Rouaud, Tiphaine, Verholleman, Audrey, Schreck, Benoit, Leboucher, Juliette, Thiabaud, Elsa, Feuillet, Fanny, Roy, Monica, Hardouin, Jean-Benoit, Guillou-Landreat, Morgane, Derkinderen, Pascal, Challet-Bouju, Gaëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872544/
https://www.ncbi.nlm.nih.gov/pubmed/35960604
http://dx.doi.org/10.1556/2006.2022.00051
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author Grall-Bronnec, Marie
Victorri-Vigneau, Caroline
Rouaud, Tiphaine
Verholleman, Audrey
Schreck, Benoit
Leboucher, Juliette
Thiabaud, Elsa
Feuillet, Fanny
Roy, Monica
Hardouin, Jean-Benoit
Guillou-Landreat, Morgane
Derkinderen, Pascal
Challet-Bouju, Gaëlle
author_facet Grall-Bronnec, Marie
Victorri-Vigneau, Caroline
Rouaud, Tiphaine
Verholleman, Audrey
Schreck, Benoit
Leboucher, Juliette
Thiabaud, Elsa
Feuillet, Fanny
Roy, Monica
Hardouin, Jean-Benoit
Guillou-Landreat, Morgane
Derkinderen, Pascal
Challet-Bouju, Gaëlle
author_sort Grall-Bronnec, Marie
collection PubMed
description BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. First-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. Unfortunately, iatrogenic impulsive-compulsive behaviors (ICBs) can occur in up to 20% of PD patients over the course of their illness. ICBs must be considered multifactorial disorders that reflect the interactions of the medication with an individual's vulnerability and the underlying neurobiology of PD. We aimed to explore the predictive genetic, psychopathological and neurological factors involved in the development of ICBs in PD patients by building a complete model of individual vulnerability. METHODS: The PARKADD study was a case/non-case study. A total of 225 patients were enrolled (“ICB” group, N = 75; “no ICB” group, N = 150), and 163 agreed to provide saliva samples for genetic analysis. Sociodemographic, neurological and psychiatric characteristics were assessed, and genotyping for the characterization of polymorphisms related to dopaminergic and opioid systems was performed. RESULTS: Factors associated with “ICBs” were younger age of PD onset, personal history of ICB prior to PD onset and higher scores on the urgency and sensation seeking facets of impulsivity. No gene variant was significantly associated, but the association with the opioid receptor mu 1 (OPRM1) rs1799971 polymorphism was close to significance. DISCUSSION AND CONCLUSIONS: The influence of gene-environment interactions probably exists, and additional studies are needed to decipher the possible role of the opioid system in the development of ICBs in PD patients.
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spelling pubmed-98725442023-02-01 Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability Grall-Bronnec, Marie Victorri-Vigneau, Caroline Rouaud, Tiphaine Verholleman, Audrey Schreck, Benoit Leboucher, Juliette Thiabaud, Elsa Feuillet, Fanny Roy, Monica Hardouin, Jean-Benoit Guillou-Landreat, Morgane Derkinderen, Pascal Challet-Bouju, Gaëlle J Behav Addict Article BACKGROUND AND AIMS: Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. First-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. Unfortunately, iatrogenic impulsive-compulsive behaviors (ICBs) can occur in up to 20% of PD patients over the course of their illness. ICBs must be considered multifactorial disorders that reflect the interactions of the medication with an individual's vulnerability and the underlying neurobiology of PD. We aimed to explore the predictive genetic, psychopathological and neurological factors involved in the development of ICBs in PD patients by building a complete model of individual vulnerability. METHODS: The PARKADD study was a case/non-case study. A total of 225 patients were enrolled (“ICB” group, N = 75; “no ICB” group, N = 150), and 163 agreed to provide saliva samples for genetic analysis. Sociodemographic, neurological and psychiatric characteristics were assessed, and genotyping for the characterization of polymorphisms related to dopaminergic and opioid systems was performed. RESULTS: Factors associated with “ICBs” were younger age of PD onset, personal history of ICB prior to PD onset and higher scores on the urgency and sensation seeking facets of impulsivity. No gene variant was significantly associated, but the association with the opioid receptor mu 1 (OPRM1) rs1799971 polymorphism was close to significance. DISCUSSION AND CONCLUSIONS: The influence of gene-environment interactions probably exists, and additional studies are needed to decipher the possible role of the opioid system in the development of ICBs in PD patients. Akadémiai Kiadó 2022-08-11 2022-09 /pmc/articles/PMC9872544/ /pubmed/35960604 http://dx.doi.org/10.1556/2006.2022.00051 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/ Open Access. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.
spellingShingle Article
Grall-Bronnec, Marie
Victorri-Vigneau, Caroline
Rouaud, Tiphaine
Verholleman, Audrey
Schreck, Benoit
Leboucher, Juliette
Thiabaud, Elsa
Feuillet, Fanny
Roy, Monica
Hardouin, Jean-Benoit
Guillou-Landreat, Morgane
Derkinderen, Pascal
Challet-Bouju, Gaëlle
Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
title Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
title_full Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
title_fullStr Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
title_full_unstemmed Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
title_short Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability
title_sort parkinson's disease and iatrogenic impulsive-compulsive behaviors: a case/non-case study to build a complete model of individual vulnerability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872544/
https://www.ncbi.nlm.nih.gov/pubmed/35960604
http://dx.doi.org/10.1556/2006.2022.00051
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