Inhibition of galectins in cancer: Biological challenges for their clinical application

Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin...

Descripción completa

Detalles Bibliográficos
Autores principales: Laderach, Diego José, Compagno, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872792/
https://www.ncbi.nlm.nih.gov/pubmed/36703969
http://dx.doi.org/10.3389/fimmu.2022.1104625
_version_ 1784877473769455616
author Laderach, Diego José
Compagno, Daniel
author_facet Laderach, Diego José
Compagno, Daniel
author_sort Laderach, Diego José
collection PubMed
description Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin inhibitors currently being evaluated and discusses some of the biological challenges that need to be addressed to improve these strategies for the benefit of cancer patients.
format Online
Article
Text
id pubmed-9872792
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98727922023-01-25 Inhibition of galectins in cancer: Biological challenges for their clinical application Laderach, Diego José Compagno, Daniel Front Immunol Immunology Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive results. This review summarizes the galectin inhibitors currently being evaluated and discusses some of the biological challenges that need to be addressed to improve these strategies for the benefit of cancer patients. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9872792/ /pubmed/36703969 http://dx.doi.org/10.3389/fimmu.2022.1104625 Text en Copyright © 2023 Laderach and Compagno https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Laderach, Diego José
Compagno, Daniel
Inhibition of galectins in cancer: Biological challenges for their clinical application
title Inhibition of galectins in cancer: Biological challenges for their clinical application
title_full Inhibition of galectins in cancer: Biological challenges for their clinical application
title_fullStr Inhibition of galectins in cancer: Biological challenges for their clinical application
title_full_unstemmed Inhibition of galectins in cancer: Biological challenges for their clinical application
title_short Inhibition of galectins in cancer: Biological challenges for their clinical application
title_sort inhibition of galectins in cancer: biological challenges for their clinical application
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872792/
https://www.ncbi.nlm.nih.gov/pubmed/36703969
http://dx.doi.org/10.3389/fimmu.2022.1104625
work_keys_str_mv AT laderachdiegojose inhibitionofgalectinsincancerbiologicalchallengesfortheirclinicalapplication
AT compagnodaniel inhibitionofgalectinsincancerbiologicalchallengesfortheirclinicalapplication

Ejemplares similares