An update on the biological characteristics and functions of tuft cells in the gut

The intestine is a powerful digestive system and one of the most sophisticated immunological organs. Evidence shows that tuft cells (TCs), a kind of epithelial cell with distinct morphological characteristics, play a significant role in various physiological processes. TCs can be broadly categorized...

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Autores principales: Du, Yixuan, Gao, Han, He, Chengwei, Xin, Shuzi, Wang, Boya, Zhang, Sitian, Gong, Fengrong, Yu, Xinyi, Pan, Luming, Sun, Fanglin, Wang, Wen, Xu, Jingdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872863/
https://www.ncbi.nlm.nih.gov/pubmed/36704202
http://dx.doi.org/10.3389/fcell.2022.1102978
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author Du, Yixuan
Gao, Han
He, Chengwei
Xin, Shuzi
Wang, Boya
Zhang, Sitian
Gong, Fengrong
Yu, Xinyi
Pan, Luming
Sun, Fanglin
Wang, Wen
Xu, Jingdong
author_facet Du, Yixuan
Gao, Han
He, Chengwei
Xin, Shuzi
Wang, Boya
Zhang, Sitian
Gong, Fengrong
Yu, Xinyi
Pan, Luming
Sun, Fanglin
Wang, Wen
Xu, Jingdong
author_sort Du, Yixuan
collection PubMed
description The intestine is a powerful digestive system and one of the most sophisticated immunological organs. Evidence shows that tuft cells (TCs), a kind of epithelial cell with distinct morphological characteristics, play a significant role in various physiological processes. TCs can be broadly categorized into different subtypes depending on different molecular criteria. In this review, we discuss its biological properties and role in maintaining homeostasis in the gastrointestinal tract. We also emphasize its relevance to the immune system and highlight its powerful influence on intestinal diseases, including inflammations and tumors. In addition, we provide fresh insights into future clinical diagnostic and therapeutic strategies related to TCs.
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spelling pubmed-98728632023-01-25 An update on the biological characteristics and functions of tuft cells in the gut Du, Yixuan Gao, Han He, Chengwei Xin, Shuzi Wang, Boya Zhang, Sitian Gong, Fengrong Yu, Xinyi Pan, Luming Sun, Fanglin Wang, Wen Xu, Jingdong Front Cell Dev Biol Cell and Developmental Biology The intestine is a powerful digestive system and one of the most sophisticated immunological organs. Evidence shows that tuft cells (TCs), a kind of epithelial cell with distinct morphological characteristics, play a significant role in various physiological processes. TCs can be broadly categorized into different subtypes depending on different molecular criteria. In this review, we discuss its biological properties and role in maintaining homeostasis in the gastrointestinal tract. We also emphasize its relevance to the immune system and highlight its powerful influence on intestinal diseases, including inflammations and tumors. In addition, we provide fresh insights into future clinical diagnostic and therapeutic strategies related to TCs. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9872863/ /pubmed/36704202 http://dx.doi.org/10.3389/fcell.2022.1102978 Text en Copyright © 2023 Du, Gao, He, Xin, Wang, Zhang, Gong, Yu, Pan, Sun, Wang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Du, Yixuan
Gao, Han
He, Chengwei
Xin, Shuzi
Wang, Boya
Zhang, Sitian
Gong, Fengrong
Yu, Xinyi
Pan, Luming
Sun, Fanglin
Wang, Wen
Xu, Jingdong
An update on the biological characteristics and functions of tuft cells in the gut
title An update on the biological characteristics and functions of tuft cells in the gut
title_full An update on the biological characteristics and functions of tuft cells in the gut
title_fullStr An update on the biological characteristics and functions of tuft cells in the gut
title_full_unstemmed An update on the biological characteristics and functions of tuft cells in the gut
title_short An update on the biological characteristics and functions of tuft cells in the gut
title_sort update on the biological characteristics and functions of tuft cells in the gut
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872863/
https://www.ncbi.nlm.nih.gov/pubmed/36704202
http://dx.doi.org/10.3389/fcell.2022.1102978
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