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Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes

Type 2 Diabetes Mellitus (T2DM) is a metabolic disease that leads to multiple vascular complications with concomitant changes in human neurophysiology, which may lead to long-term cognitive impairment, and dementia. Early impairments of neurovascular coupling can be studied using event-related funct...

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Autores principales: Duarte, João Valente, Guerra, Catarina, Moreno, Carolina, Gomes, Leonor, Castelo-Branco, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872943/
https://www.ncbi.nlm.nih.gov/pubmed/36703928
http://dx.doi.org/10.3389/fphys.2022.1101470
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author Duarte, João Valente
Guerra, Catarina
Moreno, Carolina
Gomes, Leonor
Castelo-Branco, Miguel
author_facet Duarte, João Valente
Guerra, Catarina
Moreno, Carolina
Gomes, Leonor
Castelo-Branco, Miguel
author_sort Duarte, João Valente
collection PubMed
description Type 2 Diabetes Mellitus (T2DM) is a metabolic disease that leads to multiple vascular complications with concomitant changes in human neurophysiology, which may lead to long-term cognitive impairment, and dementia. Early impairments of neurovascular coupling can be studied using event-related functional magnetic resonance imaging (fMRI) designs. Here, we aimed to characterize the changes in the hemodynamic response function (HRF) in T2DM to probe components from the initial dip to late undershoot. We investigated whether the HRF morphology is altered throughout the brain in T2DM, by extracting several parameters of the fMRI response profiles in 141 participants (64 patients with T2DM and 77 healthy controls) performing a visual motion discrimination task. Overall, the patients revealed significantly different HRFs, which extended to all brain regions, suggesting that this is a general phenomenon. The HRF in T2DM was found to be more sluggish, with a higher peak latency and lower peak amplitude, relative slope to peak, and area under the curve. It also showed a pronounced initial dip, suggesting that the initial avidity for oxygen is not compensated for, and an absent or less prominent but longer undershoot. Most HRF parameters showed a higher dispersion and variability in T2DM. In sum, we provide a definite demonstration of an impaired hemodynamic response function in the early stages of T2DM, following a previous suggestion of impaired neurovascular coupling. The quantitative demonstration of a significantly altered HRF morphology in separate response phases suggests an alteration of distinct physiological mechanisms related to neurovascular coupling, which should be considered in the future to potentially halt the deterioration of the brain function in T2DM.
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spelling pubmed-98729432023-01-25 Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes Duarte, João Valente Guerra, Catarina Moreno, Carolina Gomes, Leonor Castelo-Branco, Miguel Front Physiol Physiology Type 2 Diabetes Mellitus (T2DM) is a metabolic disease that leads to multiple vascular complications with concomitant changes in human neurophysiology, which may lead to long-term cognitive impairment, and dementia. Early impairments of neurovascular coupling can be studied using event-related functional magnetic resonance imaging (fMRI) designs. Here, we aimed to characterize the changes in the hemodynamic response function (HRF) in T2DM to probe components from the initial dip to late undershoot. We investigated whether the HRF morphology is altered throughout the brain in T2DM, by extracting several parameters of the fMRI response profiles in 141 participants (64 patients with T2DM and 77 healthy controls) performing a visual motion discrimination task. Overall, the patients revealed significantly different HRFs, which extended to all brain regions, suggesting that this is a general phenomenon. The HRF in T2DM was found to be more sluggish, with a higher peak latency and lower peak amplitude, relative slope to peak, and area under the curve. It also showed a pronounced initial dip, suggesting that the initial avidity for oxygen is not compensated for, and an absent or less prominent but longer undershoot. Most HRF parameters showed a higher dispersion and variability in T2DM. In sum, we provide a definite demonstration of an impaired hemodynamic response function in the early stages of T2DM, following a previous suggestion of impaired neurovascular coupling. The quantitative demonstration of a significantly altered HRF morphology in separate response phases suggests an alteration of distinct physiological mechanisms related to neurovascular coupling, which should be considered in the future to potentially halt the deterioration of the brain function in T2DM. Frontiers Media S.A. 2023-01-10 /pmc/articles/PMC9872943/ /pubmed/36703928 http://dx.doi.org/10.3389/fphys.2022.1101470 Text en Copyright © 2023 Duarte, Guerra, Moreno, Gomes and Castelo-Branco. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Duarte, João Valente
Guerra, Catarina
Moreno, Carolina
Gomes, Leonor
Castelo-Branco, Miguel
Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
title Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
title_full Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
title_fullStr Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
title_full_unstemmed Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
title_short Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
title_sort changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872943/
https://www.ncbi.nlm.nih.gov/pubmed/36703928
http://dx.doi.org/10.3389/fphys.2022.1101470
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