Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features

Over the last three decades, the appeal for monoclonal antibodies (mAbs) as therapeutics has been steadily increasing as evident with FDA’s recent landmark approval of the 100th mAb. Unlike mAbs that bind to single targets, multispecific biologics (msAbs) have garnered particular interest owing to t...

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Detalles Bibliográficos
Autores principales: Harmalkar, Ameya, Rao, Roshan, Richard Xie, Yuxuan, Honer, Jonas, Deisting, Wibke, Anlahr, Jonas, Hoenig, Anja, Czwikla, Julia, Sienz-Widmann, Eva, Rau, Doris, Rice, Austin J., Riley, Timothy P., Li, Danqing, Catterall, Hannah B., Tinberg, Christine E., Gray, Jeffrey J., Wei, Kathy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872953/
https://www.ncbi.nlm.nih.gov/pubmed/36683173
http://dx.doi.org/10.1080/19420862.2022.2163584

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