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Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer

BACKGROUND: The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood. Therefore, in our study, we investigated the effects of the various immune cells infiltration in tumor microenvironment...

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Autores principales: Tanaka, Ryota, Eguchi, Shimpei, Kimura, Kenjiro, Ohira, Go, Tanaka, Shogo, Amano, Ryosuke, Tanaka, Hiroaki, Yashiro, Masakazu, Ohira, Masaichi, Kubo, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873170/
https://www.ncbi.nlm.nih.gov/pubmed/36693070
http://dx.doi.org/10.1371/journal.pone.0280348
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author Tanaka, Ryota
Eguchi, Shimpei
Kimura, Kenjiro
Ohira, Go
Tanaka, Shogo
Amano, Ryosuke
Tanaka, Hiroaki
Yashiro, Masakazu
Ohira, Masaichi
Kubo, Shoji
author_facet Tanaka, Ryota
Eguchi, Shimpei
Kimura, Kenjiro
Ohira, Go
Tanaka, Shogo
Amano, Ryosuke
Tanaka, Hiroaki
Yashiro, Masakazu
Ohira, Masaichi
Kubo, Shoji
author_sort Tanaka, Ryota
collection PubMed
description BACKGROUND: The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood. Therefore, in our study, we investigated the effects of the various immune cells infiltration in tumor microenvironment (TME). METHODS: A total of 130 patients with BTC who underwent surgical treatment at our institution were enrolled in this study. We retrospectively evaluated TILs and TAMs with immunohistochemical staining. RESULTS: With CD8-high, CD4-high, FOXP3-high, and CD68-low in TME as one factor, we calculated Immunoscore according to the number of factors. The high Immunoscore group showed significantly superior overall survival (OS) and recurrence-free survival (RFS) than the low Immunoscore group (median OS, 60.8 vs. 26.4 months, p = 0.001; median RFS not reached vs. 17.2 months, p < 0.001). Also, high Immunoscore was an independent good prognostic factor for OS and RFS (hazards ratio 2.05 and 2.41 and p = 0.01 and p = 0.001, respectively). CONCLUSIONS: High Immunoscore group had significantly superior OS and RFS and was an independent good prognostic factor for OS and RFS.
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spelling pubmed-98731702023-01-25 Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer Tanaka, Ryota Eguchi, Shimpei Kimura, Kenjiro Ohira, Go Tanaka, Shogo Amano, Ryosuke Tanaka, Hiroaki Yashiro, Masakazu Ohira, Masaichi Kubo, Shoji PLoS One Research Article BACKGROUND: The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood. Therefore, in our study, we investigated the effects of the various immune cells infiltration in tumor microenvironment (TME). METHODS: A total of 130 patients with BTC who underwent surgical treatment at our institution were enrolled in this study. We retrospectively evaluated TILs and TAMs with immunohistochemical staining. RESULTS: With CD8-high, CD4-high, FOXP3-high, and CD68-low in TME as one factor, we calculated Immunoscore according to the number of factors. The high Immunoscore group showed significantly superior overall survival (OS) and recurrence-free survival (RFS) than the low Immunoscore group (median OS, 60.8 vs. 26.4 months, p = 0.001; median RFS not reached vs. 17.2 months, p < 0.001). Also, high Immunoscore was an independent good prognostic factor for OS and RFS (hazards ratio 2.05 and 2.41 and p = 0.01 and p = 0.001, respectively). CONCLUSIONS: High Immunoscore group had significantly superior OS and RFS and was an independent good prognostic factor for OS and RFS. Public Library of Science 2023-01-24 /pmc/articles/PMC9873170/ /pubmed/36693070 http://dx.doi.org/10.1371/journal.pone.0280348 Text en © 2023 Tanaka et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tanaka, Ryota
Eguchi, Shimpei
Kimura, Kenjiro
Ohira, Go
Tanaka, Shogo
Amano, Ryosuke
Tanaka, Hiroaki
Yashiro, Masakazu
Ohira, Masaichi
Kubo, Shoji
Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
title Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
title_full Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
title_fullStr Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
title_full_unstemmed Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
title_short Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
title_sort tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873170/
https://www.ncbi.nlm.nih.gov/pubmed/36693070
http://dx.doi.org/10.1371/journal.pone.0280348
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