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Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders
Patients suffering from chronic diseases are more likely to experience pDDIs due to older age, prolonged treatment, severe illness and greater number of prescribed drugs. The objective of the current study was to assess the prevalence of pDDIs and risk factors associated with occurrence of pDDIs in...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873175/ https://www.ncbi.nlm.nih.gov/pubmed/36693042 http://dx.doi.org/10.1371/journal.pone.0276277 |
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author | Rasool, Muhammad Fawad Rehman, Anees ur Khan, Irfanullah Latif, Muhammad Ahmad, Imran Shakeel, Sadia Sadiq, Muhammad Hayat, Khezar Shah, Shahid Ashraf, Waseem Majeed, Abdul Hussain, Iltaf Hussain, Rabia |
author_facet | Rasool, Muhammad Fawad Rehman, Anees ur Khan, Irfanullah Latif, Muhammad Ahmad, Imran Shakeel, Sadia Sadiq, Muhammad Hayat, Khezar Shah, Shahid Ashraf, Waseem Majeed, Abdul Hussain, Iltaf Hussain, Rabia |
author_sort | Rasool, Muhammad Fawad |
collection | PubMed |
description | Patients suffering from chronic diseases are more likely to experience pDDIs due to older age, prolonged treatment, severe illness and greater number of prescribed drugs. The objective of the current study was to assess the prevalence of pDDIs and risk factors associated with occurrence of pDDIs in chronic disease patients attending outpatient clinics for regular check-ups. Patients suffering from diabetes, chronic obstructive pulmonary disease (COPD), stroke and osteoporosis were included in the study. This study was a cross sectional, observational, prospective study that included 337 patients from outpatient clinics of respiratory ward, cardiac ward and orthopedic ward of Nishter Hospital Multan, Pakistan. The mean number of interactions per patient was 1.68. A greater risk for occurrence of pDDI was associated with older age ≥ 60 years (OR = 1.95, 95% CI = 1.44–2.37, p<0.001); polypharmacy (≥ 5 drugs) (OR = 3.74, 95% CI 2.32–4.54, p<0.001); overburden (OR = 2.23, 95% CI = 1.64–3.16, p<0.01); CCI score (OR = 1.28, 95% CI = 1.04–1.84, p<0.001); multiple prescribers to one patient (OR = 1.18, 95% CI = 1.06–1.41, p<0.01); and trainee practitioner (OR = 1.09, 95% CI = 1.01–1.28, p<0.01). Old age, polypharmacy, overburden healthcare system, higher comorbidity index, multiple prescribers to one patient and trainee practitioner were associated with increased risk of occurrence of pDDIs in chronic disease patients. |
format | Online Article Text |
id | pubmed-9873175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98731752023-01-25 Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders Rasool, Muhammad Fawad Rehman, Anees ur Khan, Irfanullah Latif, Muhammad Ahmad, Imran Shakeel, Sadia Sadiq, Muhammad Hayat, Khezar Shah, Shahid Ashraf, Waseem Majeed, Abdul Hussain, Iltaf Hussain, Rabia PLoS One Research Article Patients suffering from chronic diseases are more likely to experience pDDIs due to older age, prolonged treatment, severe illness and greater number of prescribed drugs. The objective of the current study was to assess the prevalence of pDDIs and risk factors associated with occurrence of pDDIs in chronic disease patients attending outpatient clinics for regular check-ups. Patients suffering from diabetes, chronic obstructive pulmonary disease (COPD), stroke and osteoporosis were included in the study. This study was a cross sectional, observational, prospective study that included 337 patients from outpatient clinics of respiratory ward, cardiac ward and orthopedic ward of Nishter Hospital Multan, Pakistan. The mean number of interactions per patient was 1.68. A greater risk for occurrence of pDDI was associated with older age ≥ 60 years (OR = 1.95, 95% CI = 1.44–2.37, p<0.001); polypharmacy (≥ 5 drugs) (OR = 3.74, 95% CI 2.32–4.54, p<0.001); overburden (OR = 2.23, 95% CI = 1.64–3.16, p<0.01); CCI score (OR = 1.28, 95% CI = 1.04–1.84, p<0.001); multiple prescribers to one patient (OR = 1.18, 95% CI = 1.06–1.41, p<0.01); and trainee practitioner (OR = 1.09, 95% CI = 1.01–1.28, p<0.01). Old age, polypharmacy, overburden healthcare system, higher comorbidity index, multiple prescribers to one patient and trainee practitioner were associated with increased risk of occurrence of pDDIs in chronic disease patients. Public Library of Science 2023-01-24 /pmc/articles/PMC9873175/ /pubmed/36693042 http://dx.doi.org/10.1371/journal.pone.0276277 Text en © 2023 Rasool et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rasool, Muhammad Fawad Rehman, Anees ur Khan, Irfanullah Latif, Muhammad Ahmad, Imran Shakeel, Sadia Sadiq, Muhammad Hayat, Khezar Shah, Shahid Ashraf, Waseem Majeed, Abdul Hussain, Iltaf Hussain, Rabia Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
title | Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
title_full | Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
title_fullStr | Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
title_full_unstemmed | Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
title_short | Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
title_sort | assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873175/ https://www.ncbi.nlm.nih.gov/pubmed/36693042 http://dx.doi.org/10.1371/journal.pone.0276277 |
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