Syntheses and Structure–Activity Relationships of N-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome bd Oxidase in Mycobacterium tuberculosis

The development of cytochrome bd oxidase (cyt-bd) inhibitors are needed for comprehensive termination of energy production in Mycobacterium tuberculosis (Mtb) to treat tuberculosis infections. Herein, we report on the structure-activity-relationships (SAR) of 22 new N-phenethyl-quinazolin-4-yl-amine...

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Detalles Bibliográficos
Autores principales: Hopfner, Sarah M., Lee, Bei Shi, Kalia, Nitin P., Miller, Marvin J., Pethe, Kevin, Moraski, Garrett C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873234/
https://www.ncbi.nlm.nih.gov/pubmed/36698770
http://dx.doi.org/10.3390/app11199092

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