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Selective integration of diverse taste inputs within a single taste modality

A fundamental question in sensory processing is how different channels of sensory input are processed to regulate behavior. Different input channels may converge onto common downstream pathways to drive the same behaviors, or they may activate separate pathways to regulate distinct behaviors. We inv...

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Autores principales: Deere, Julia U, Sarkissian, Arvin A, Yang, Meifeng, Uttley, Hannah A, Martinez Santana, Nicole, Nguyen, Lam, Ravi, Kaushiki, Devineni, Anita V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873257/
https://www.ncbi.nlm.nih.gov/pubmed/36692370
http://dx.doi.org/10.7554/eLife.84856
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author Deere, Julia U
Sarkissian, Arvin A
Yang, Meifeng
Uttley, Hannah A
Martinez Santana, Nicole
Nguyen, Lam
Ravi, Kaushiki
Devineni, Anita V
author_facet Deere, Julia U
Sarkissian, Arvin A
Yang, Meifeng
Uttley, Hannah A
Martinez Santana, Nicole
Nguyen, Lam
Ravi, Kaushiki
Devineni, Anita V
author_sort Deere, Julia U
collection PubMed
description A fundamental question in sensory processing is how different channels of sensory input are processed to regulate behavior. Different input channels may converge onto common downstream pathways to drive the same behaviors, or they may activate separate pathways to regulate distinct behaviors. We investigated this question in the Drosophila bitter taste system, which contains diverse bitter-sensing cells residing in different taste organs. First, we optogenetically activated subsets of bitter neurons within each organ. These subsets elicited broad and highly overlapping behavioral effects, suggesting that they converge onto common downstream pathways, but we also observed behavioral differences that argue for biased convergence. Consistent with these results, transsynaptic tracing revealed that bitter neurons in different organs connect to overlapping downstream pathways with biased connectivity. We investigated taste processing in one type of downstream bitter neuron that projects to the higher brain. These neurons integrate input from multiple organs and regulate specific taste-related behaviors. We then traced downstream circuits, providing the first glimpse into taste processing in the higher brain. Together, these results reveal that different bitter inputs are selectively integrated early in the circuit, enabling the pooling of information, while the circuit then diverges into multiple pathways that may have different roles.
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spelling pubmed-98732572023-01-25 Selective integration of diverse taste inputs within a single taste modality Deere, Julia U Sarkissian, Arvin A Yang, Meifeng Uttley, Hannah A Martinez Santana, Nicole Nguyen, Lam Ravi, Kaushiki Devineni, Anita V eLife Neuroscience A fundamental question in sensory processing is how different channels of sensory input are processed to regulate behavior. Different input channels may converge onto common downstream pathways to drive the same behaviors, or they may activate separate pathways to regulate distinct behaviors. We investigated this question in the Drosophila bitter taste system, which contains diverse bitter-sensing cells residing in different taste organs. First, we optogenetically activated subsets of bitter neurons within each organ. These subsets elicited broad and highly overlapping behavioral effects, suggesting that they converge onto common downstream pathways, but we also observed behavioral differences that argue for biased convergence. Consistent with these results, transsynaptic tracing revealed that bitter neurons in different organs connect to overlapping downstream pathways with biased connectivity. We investigated taste processing in one type of downstream bitter neuron that projects to the higher brain. These neurons integrate input from multiple organs and regulate specific taste-related behaviors. We then traced downstream circuits, providing the first glimpse into taste processing in the higher brain. Together, these results reveal that different bitter inputs are selectively integrated early in the circuit, enabling the pooling of information, while the circuit then diverges into multiple pathways that may have different roles. eLife Sciences Publications, Ltd 2023-01-24 /pmc/articles/PMC9873257/ /pubmed/36692370 http://dx.doi.org/10.7554/eLife.84856 Text en © 2023, Deere et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Deere, Julia U
Sarkissian, Arvin A
Yang, Meifeng
Uttley, Hannah A
Martinez Santana, Nicole
Nguyen, Lam
Ravi, Kaushiki
Devineni, Anita V
Selective integration of diverse taste inputs within a single taste modality
title Selective integration of diverse taste inputs within a single taste modality
title_full Selective integration of diverse taste inputs within a single taste modality
title_fullStr Selective integration of diverse taste inputs within a single taste modality
title_full_unstemmed Selective integration of diverse taste inputs within a single taste modality
title_short Selective integration of diverse taste inputs within a single taste modality
title_sort selective integration of diverse taste inputs within a single taste modality
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873257/
https://www.ncbi.nlm.nih.gov/pubmed/36692370
http://dx.doi.org/10.7554/eLife.84856
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