Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy

Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also sh...

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Autores principales: Udden, S. M. Nashir, Baek, GuemHee, Pandey, Kamal, Vidal, Chantal, Liu, Yulun, Rahimi, Asal S., Kim, D. Nathan, Nwachukwu, Chika R., Mani, Ram S., Alluri, Prasanna G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873388/
https://www.ncbi.nlm.nih.gov/pubmed/36693944
http://dx.doi.org/10.1038/s41698-023-00348-1
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author Udden, S. M. Nashir
Baek, GuemHee
Pandey, Kamal
Vidal, Chantal
Liu, Yulun
Rahimi, Asal S.
Kim, D. Nathan
Nwachukwu, Chika R.
Mani, Ram S.
Alluri, Prasanna G.
author_facet Udden, S. M. Nashir
Baek, GuemHee
Pandey, Kamal
Vidal, Chantal
Liu, Yulun
Rahimi, Asal S.
Kim, D. Nathan
Nwachukwu, Chika R.
Mani, Ram S.
Alluri, Prasanna G.
author_sort Udden, S. M. Nashir
collection PubMed
description Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.
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spelling pubmed-98733882023-01-25 Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy Udden, S. M. Nashir Baek, GuemHee Pandey, Kamal Vidal, Chantal Liu, Yulun Rahimi, Asal S. Kim, D. Nathan Nwachukwu, Chika R. Mani, Ram S. Alluri, Prasanna G. NPJ Precis Oncol Brief Communication Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy. Nature Publishing Group UK 2023-01-24 /pmc/articles/PMC9873388/ /pubmed/36693944 http://dx.doi.org/10.1038/s41698-023-00348-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Udden, S. M. Nashir
Baek, GuemHee
Pandey, Kamal
Vidal, Chantal
Liu, Yulun
Rahimi, Asal S.
Kim, D. Nathan
Nwachukwu, Chika R.
Mani, Ram S.
Alluri, Prasanna G.
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
title Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
title_full Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
title_fullStr Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
title_full_unstemmed Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
title_short Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
title_sort towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873388/
https://www.ncbi.nlm.nih.gov/pubmed/36693944
http://dx.doi.org/10.1038/s41698-023-00348-1
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