Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation

We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute...

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Detalles Bibliográficos
Autores principales: Hosokawa, Yuka, Toubai, Tomomi, Ohe, Rintaro, Hosokawa, Masashi, Sato, Ryo, Yamada, Akane, Aizawa, Keiko, Himuro, Masahito, Ito, Satoshi, Yamamoto, Masakazu, Peltier, Daniel, Ishizawa, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia-Pacific Blood and Marrow Transplantation Group 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873419/
https://www.ncbi.nlm.nih.gov/pubmed/36712552
http://dx.doi.org/10.31547/bct-2021-023
Descripción
Sumario:We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute pancreatitis was suspected, no structural lesions were detected. Liver biopsy was compatible with late-onset acute graft-versus-host disease (GVHD), which resolved following treatment with methylprednisolone (mPSL) and tacrolimus (TAC). In addition, her serum amylase level and abdominal pain rapidly resolved following acute GVHD-directed therapy. Acute pancreatitis concomitant with late-onset acute liver GVHD is extremely rare and has not been documented subsequent to a second allo-HCT.

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