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Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia-Pacific Blood and Marrow Transplantation Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873419/ https://www.ncbi.nlm.nih.gov/pubmed/36712552 http://dx.doi.org/10.31547/bct-2021-023 |
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author | Hosokawa, Yuka Toubai, Tomomi Ohe, Rintaro Hosokawa, Masashi Sato, Ryo Yamada, Akane Aizawa, Keiko Himuro, Masahito Ito, Satoshi Yamamoto, Masakazu Peltier, Daniel Ishizawa, Kenichi |
author_facet | Hosokawa, Yuka Toubai, Tomomi Ohe, Rintaro Hosokawa, Masashi Sato, Ryo Yamada, Akane Aizawa, Keiko Himuro, Masahito Ito, Satoshi Yamamoto, Masakazu Peltier, Daniel Ishizawa, Kenichi |
author_sort | Hosokawa, Yuka |
collection | PubMed |
description | We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute pancreatitis was suspected, no structural lesions were detected. Liver biopsy was compatible with late-onset acute graft-versus-host disease (GVHD), which resolved following treatment with methylprednisolone (mPSL) and tacrolimus (TAC). In addition, her serum amylase level and abdominal pain rapidly resolved following acute GVHD-directed therapy. Acute pancreatitis concomitant with late-onset acute liver GVHD is extremely rare and has not been documented subsequent to a second allo-HCT. |
format | Online Article Text |
id | pubmed-9873419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Asia-Pacific Blood and Marrow Transplantation Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-98734192023-01-27 Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation Hosokawa, Yuka Toubai, Tomomi Ohe, Rintaro Hosokawa, Masashi Sato, Ryo Yamada, Akane Aizawa, Keiko Himuro, Masahito Ito, Satoshi Yamamoto, Masakazu Peltier, Daniel Ishizawa, Kenichi Blood Cell Ther Case Report We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute pancreatitis was suspected, no structural lesions were detected. Liver biopsy was compatible with late-onset acute graft-versus-host disease (GVHD), which resolved following treatment with methylprednisolone (mPSL) and tacrolimus (TAC). In addition, her serum amylase level and abdominal pain rapidly resolved following acute GVHD-directed therapy. Acute pancreatitis concomitant with late-onset acute liver GVHD is extremely rare and has not been documented subsequent to a second allo-HCT. Asia-Pacific Blood and Marrow Transplantation Group 2022-06-03 /pmc/articles/PMC9873419/ /pubmed/36712552 http://dx.doi.org/10.31547/bct-2021-023 Text en Copyright Ⓒ2022 Asia-Pacific Blood and Marrow Transplantation Group (APBMT). https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Case Report Hosokawa, Yuka Toubai, Tomomi Ohe, Rintaro Hosokawa, Masashi Sato, Ryo Yamada, Akane Aizawa, Keiko Himuro, Masahito Ito, Satoshi Yamamoto, Masakazu Peltier, Daniel Ishizawa, Kenichi Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation |
title | Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation |
title_full | Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation |
title_fullStr | Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation |
title_full_unstemmed | Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation |
title_short | Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation |
title_sort | successful treatment of acute pancreatitis associated with late-onset acute liver gvhd after second allogeneic hematopoietic cell transplantation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873419/ https://www.ncbi.nlm.nih.gov/pubmed/36712552 http://dx.doi.org/10.31547/bct-2021-023 |
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