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Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation

We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute...

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Autores principales: Hosokawa, Yuka, Toubai, Tomomi, Ohe, Rintaro, Hosokawa, Masashi, Sato, Ryo, Yamada, Akane, Aizawa, Keiko, Himuro, Masahito, Ito, Satoshi, Yamamoto, Masakazu, Peltier, Daniel, Ishizawa, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia-Pacific Blood and Marrow Transplantation Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873419/
https://www.ncbi.nlm.nih.gov/pubmed/36712552
http://dx.doi.org/10.31547/bct-2021-023
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author Hosokawa, Yuka
Toubai, Tomomi
Ohe, Rintaro
Hosokawa, Masashi
Sato, Ryo
Yamada, Akane
Aizawa, Keiko
Himuro, Masahito
Ito, Satoshi
Yamamoto, Masakazu
Peltier, Daniel
Ishizawa, Kenichi
author_facet Hosokawa, Yuka
Toubai, Tomomi
Ohe, Rintaro
Hosokawa, Masashi
Sato, Ryo
Yamada, Akane
Aizawa, Keiko
Himuro, Masahito
Ito, Satoshi
Yamamoto, Masakazu
Peltier, Daniel
Ishizawa, Kenichi
author_sort Hosokawa, Yuka
collection PubMed
description We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute pancreatitis was suspected, no structural lesions were detected. Liver biopsy was compatible with late-onset acute graft-versus-host disease (GVHD), which resolved following treatment with methylprednisolone (mPSL) and tacrolimus (TAC). In addition, her serum amylase level and abdominal pain rapidly resolved following acute GVHD-directed therapy. Acute pancreatitis concomitant with late-onset acute liver GVHD is extremely rare and has not been documented subsequent to a second allo-HCT.
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spelling pubmed-98734192023-01-27 Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation Hosokawa, Yuka Toubai, Tomomi Ohe, Rintaro Hosokawa, Masashi Sato, Ryo Yamada, Akane Aizawa, Keiko Himuro, Masahito Ito, Satoshi Yamamoto, Masakazu Peltier, Daniel Ishizawa, Kenichi Blood Cell Ther Case Report We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute pancreatitis was suspected, no structural lesions were detected. Liver biopsy was compatible with late-onset acute graft-versus-host disease (GVHD), which resolved following treatment with methylprednisolone (mPSL) and tacrolimus (TAC). In addition, her serum amylase level and abdominal pain rapidly resolved following acute GVHD-directed therapy. Acute pancreatitis concomitant with late-onset acute liver GVHD is extremely rare and has not been documented subsequent to a second allo-HCT. Asia-Pacific Blood and Marrow Transplantation Group 2022-06-03 /pmc/articles/PMC9873419/ /pubmed/36712552 http://dx.doi.org/10.31547/bct-2021-023 Text en Copyright Ⓒ2022 Asia-Pacific Blood and Marrow Transplantation Group (APBMT). https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Case Report
Hosokawa, Yuka
Toubai, Tomomi
Ohe, Rintaro
Hosokawa, Masashi
Sato, Ryo
Yamada, Akane
Aizawa, Keiko
Himuro, Masahito
Ito, Satoshi
Yamamoto, Masakazu
Peltier, Daniel
Ishizawa, Kenichi
Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
title Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
title_full Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
title_fullStr Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
title_full_unstemmed Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
title_short Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation
title_sort successful treatment of acute pancreatitis associated with late-onset acute liver gvhd after second allogeneic hematopoietic cell transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873419/
https://www.ncbi.nlm.nih.gov/pubmed/36712552
http://dx.doi.org/10.31547/bct-2021-023
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