Autologous T cell therapy for MAGE-A4(+) solid cancers in HLA-A*02(+) patients: a phase 1 trial

Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell therapy targeting melanoma-associated antigen A4 (MAGE-A4), a cancer/testis antigen expressed at varying levels in mu...

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Detalles Bibliográficos
Autores principales: Hong, David S., Van Tine, Brian A., Biswas, Swethajit, McAlpine, Cheryl, Johnson, Melissa L., Olszanski, Anthony J., Clarke, Jeffrey M., Araujo, Dejka, Blumenschein, George R., Kebriaei, Partow, Lin, Quan, Tipping, Alex J., Sanderson, Joseph P., Wang, Ruoxi, Trivedi, Trupti, Annareddy, Thejo, Bai, Jane, Rafail, Stavros, Sun, Amy, Fernandes, Lilliam, Navenot, Jean-Marc, Bushman, Frederic D., Everett, John K., Karadeniz, Derin, Broad, Robyn, Isabelle, Martin, Naidoo, Revashnee, Bath, Natalie, Betts, Gareth, Wolchinsky, Zohar, Batrakou, Dzmitry G., Van Winkle, Erin, Elefant, Erica, Ghobadi, Armin, Cashen, Amanda, Grand’Maison, Anne, McCarthy, Philip, Fracasso, Paula M., Norry, Elliot, Williams, Dennis, Druta, Mihaela, Liebner, David A., Odunsi, Kunle, Butler, Marcus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873554/
https://www.ncbi.nlm.nih.gov/pubmed/36624315
http://dx.doi.org/10.1038/s41591-022-02128-z

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