A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a deficiency in repairing DNA crosslinks, which are known to perturb several cellular processes, including DNA transcription, replication, and repair. Formaldehyde, a by-product of metabolism, is thought to drive F...

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Detalles Bibliográficos
Autores principales: Gao, Yuandi, Guitton-Sert, Laure, Dessapt, Julien, Coulombe, Yan, Rodrigue, Amélie, Milano, Larissa, Blondeau, Andréanne, Larsen, Nicolai Balle, Duxin, Julien P., Hussein, Samer, Fradet-Turcotte, Amélie, Masson, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873647/
https://www.ncbi.nlm.nih.gov/pubmed/36693839
http://dx.doi.org/10.1038/s41467-023-35802-y

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