Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an original approach to select the ensemble of folded proteins...

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Detalles Bibliográficos
Autores principales: Gomes, M., Fleck, A., Degaugue, A., Gourmelon, F., Léger, C., Aumont-Nicaise, M., Mesneau, A., Jean-Jacques, H., Hassaine, G., Urvoas, A., Minard, P., Valerio-Lepiniec, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873692/
https://www.ncbi.nlm.nih.gov/pubmed/36693880
http://dx.doi.org/10.1038/s41598-023-27710-4

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