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The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target

Diffuse gastric mucosal injury is a chronic injury with altered cell differentiation, including spasmolytic polypeptide expression metaplasia (SPEM) and intestinal metaplasia (IM), which are considered precancerous lesions of gastric cancer (GC). Previously, most studies have focused on how parietal...

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Autores principales: Deng, Zilin, Zhu, Jiaxing, Ma, Zhiyuan, Yi, Zhiqiang, Tuo, Biguang, Li, Taolang, Liu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873797/
https://www.ncbi.nlm.nih.gov/pubmed/36693845
http://dx.doi.org/10.1038/s41420-023-01318-z
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author Deng, Zilin
Zhu, Jiaxing
Ma, Zhiyuan
Yi, Zhiqiang
Tuo, Biguang
Li, Taolang
Liu, Xuemei
author_facet Deng, Zilin
Zhu, Jiaxing
Ma, Zhiyuan
Yi, Zhiqiang
Tuo, Biguang
Li, Taolang
Liu, Xuemei
author_sort Deng, Zilin
collection PubMed
description Diffuse gastric mucosal injury is a chronic injury with altered cell differentiation, including spasmolytic polypeptide expression metaplasia (SPEM) and intestinal metaplasia (IM), which are considered precancerous lesions of gastric cancer (GC). Previously, most studies have focused on how parietal cell loss causes SPEM through transdifferentiation of chief cells. In theory, alteration or loss of chief cells seems to be a secondary phenomenon due to initial partial cell loss. However, whether initial chief cell loss causes SPEM needs to be further investigated. Currently, increasing evidence shows that initial chief cell loss is sufficient to induce gastric mucosal injury, including SPEM and IM, and ultimately lead to GC. Therefore, we summarized the two main types of models that explain the development of gastric mucosal injury due to initial chief cell loss. We hope to provide a novel perspective for the prevention and treatment of diffuse gastric mucosal injury.
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spelling pubmed-98737972023-01-26 The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target Deng, Zilin Zhu, Jiaxing Ma, Zhiyuan Yi, Zhiqiang Tuo, Biguang Li, Taolang Liu, Xuemei Cell Death Discov Review Article Diffuse gastric mucosal injury is a chronic injury with altered cell differentiation, including spasmolytic polypeptide expression metaplasia (SPEM) and intestinal metaplasia (IM), which are considered precancerous lesions of gastric cancer (GC). Previously, most studies have focused on how parietal cell loss causes SPEM through transdifferentiation of chief cells. In theory, alteration or loss of chief cells seems to be a secondary phenomenon due to initial partial cell loss. However, whether initial chief cell loss causes SPEM needs to be further investigated. Currently, increasing evidence shows that initial chief cell loss is sufficient to induce gastric mucosal injury, including SPEM and IM, and ultimately lead to GC. Therefore, we summarized the two main types of models that explain the development of gastric mucosal injury due to initial chief cell loss. We hope to provide a novel perspective for the prevention and treatment of diffuse gastric mucosal injury. Nature Publishing Group UK 2023-01-24 /pmc/articles/PMC9873797/ /pubmed/36693845 http://dx.doi.org/10.1038/s41420-023-01318-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Deng, Zilin
Zhu, Jiaxing
Ma, Zhiyuan
Yi, Zhiqiang
Tuo, Biguang
Li, Taolang
Liu, Xuemei
The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
title The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
title_full The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
title_fullStr The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
title_full_unstemmed The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
title_short The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
title_sort mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873797/
https://www.ncbi.nlm.nih.gov/pubmed/36693845
http://dx.doi.org/10.1038/s41420-023-01318-z
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