Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer

In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.(1) By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved...

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Detalles Bibliográficos
Autores principales: Anandappa, Gayathri, Overman, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873932/
https://www.ncbi.nlm.nih.gov/pubmed/36652917
http://dx.doi.org/10.1016/j.xcrm.2022.100908
Descripción
Sumario:In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.(1) By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved tumor control in murine models.

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