Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer

In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.(1) By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved...

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Detalles Bibliográficos
Autores principales: Anandappa, Gayathri, Overman, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873932/
https://www.ncbi.nlm.nih.gov/pubmed/36652917
http://dx.doi.org/10.1016/j.xcrm.2022.100908
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author Anandappa, Gayathri
Overman, Michael J.
author_facet Anandappa, Gayathri
Overman, Michael J.
author_sort Anandappa, Gayathri
collection PubMed
description In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.(1) By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved tumor control in murine models.
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spelling pubmed-98739322023-01-26 Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer Anandappa, Gayathri Overman, Michael J. Cell Rep Med Spotlight In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.(1) By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved tumor control in murine models. Elsevier 2023-01-17 /pmc/articles/PMC9873932/ /pubmed/36652917 http://dx.doi.org/10.1016/j.xcrm.2022.100908 Text en © 2022. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Spotlight
Anandappa, Gayathri
Overman, Michael J.
Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
title Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
title_full Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
title_fullStr Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
title_full_unstemmed Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
title_short Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
title_sort harnessing the therapeutic vulnerability of mmr heterogeneity in colorectal cancer
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873932/
https://www.ncbi.nlm.nih.gov/pubmed/36652917
http://dx.doi.org/10.1016/j.xcrm.2022.100908
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