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Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.(1) By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873932/ https://www.ncbi.nlm.nih.gov/pubmed/36652917 http://dx.doi.org/10.1016/j.xcrm.2022.100908 |