Illuminating the mechanism of IL-6-mediated immunotherapy resistance

Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.

Detalles Bibliográficos
Autor principal: Vilgelm, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873941/
https://www.ncbi.nlm.nih.gov/pubmed/36652910
http://dx.doi.org/10.1016/j.xcrm.2022.100901
Descripción
Sumario:Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.

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