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Illuminating the mechanism of IL-6-mediated immunotherapy resistance
Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873941/ https://www.ncbi.nlm.nih.gov/pubmed/36652910 http://dx.doi.org/10.1016/j.xcrm.2022.100901 |
| _version_ | 1784877692799156224 |
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| author | Vilgelm, Anna E. |
| author_facet | Vilgelm, Anna E. |
| author_sort | Vilgelm, Anna E. |
| collection | PubMed |
| description | Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy. |
| format | Online Article Text |
| id | pubmed-9873941 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98739412023-01-26 Illuminating the mechanism of IL-6-mediated immunotherapy resistance Vilgelm, Anna E. Cell Rep Med Preview Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy. Elsevier 2023-01-17 /pmc/articles/PMC9873941/ /pubmed/36652910 http://dx.doi.org/10.1016/j.xcrm.2022.100901 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Vilgelm, Anna E. Illuminating the mechanism of IL-6-mediated immunotherapy resistance |
| title | Illuminating the mechanism of IL-6-mediated immunotherapy resistance |
| title_full | Illuminating the mechanism of IL-6-mediated immunotherapy resistance |
| title_fullStr | Illuminating the mechanism of IL-6-mediated immunotherapy resistance |
| title_full_unstemmed | Illuminating the mechanism of IL-6-mediated immunotherapy resistance |
| title_short | Illuminating the mechanism of IL-6-mediated immunotherapy resistance |
| title_sort | illuminating the mechanism of il-6-mediated immunotherapy resistance |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873941/ https://www.ncbi.nlm.nih.gov/pubmed/36652910 http://dx.doi.org/10.1016/j.xcrm.2022.100901 |
| work_keys_str_mv | AT vilgelmannae illuminatingthemechanismofil6mediatedimmunotherapyresistance |