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Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation

OBJECTIVE: To examine the changes in total kidney volume (TKV) and total liver volume (TLV) before and after dialysis initiation in patients with autosomal dominant polycystic kidney disease. PATIENTS AND METHODS: This was a retrospective, single-center cohort study to investigate the changes in TKV...

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Autores principales: Suwabe, Tatsuya, Ubara, Yoshifumi, Oba, Yuki, Mizuno, Hiroki, Ikuma, Daisuke, Yamanouchi, Masayuki, Sekine, Akinari, Tanaka, Kiho, Hasegawa, Eiko, Hoshino, Junichi, Sawa, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873948/
https://www.ncbi.nlm.nih.gov/pubmed/36712823
http://dx.doi.org/10.1016/j.mayocpiqo.2022.12.005
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author Suwabe, Tatsuya
Ubara, Yoshifumi
Oba, Yuki
Mizuno, Hiroki
Ikuma, Daisuke
Yamanouchi, Masayuki
Sekine, Akinari
Tanaka, Kiho
Hasegawa, Eiko
Hoshino, Junichi
Sawa, Naoki
author_facet Suwabe, Tatsuya
Ubara, Yoshifumi
Oba, Yuki
Mizuno, Hiroki
Ikuma, Daisuke
Yamanouchi, Masayuki
Sekine, Akinari
Tanaka, Kiho
Hasegawa, Eiko
Hoshino, Junichi
Sawa, Naoki
author_sort Suwabe, Tatsuya
collection PubMed
description OBJECTIVE: To examine the changes in total kidney volume (TKV) and total liver volume (TLV) before and after dialysis initiation in patients with autosomal dominant polycystic kidney disease. PATIENTS AND METHODS: This was a retrospective, single-center cohort study to investigate the changes in TKV and TLV before and after dialysis initiation, along with influencing factors, using linear mixed models. We enrolled 95 patients with autosomal dominant polycystic kidney disease (85 receiving hemodialysis [HD] and 10 receiving peritoneal dialysis [PD]) who began receiving dialysis at Toranomon Hospital from January 1, 2008, to December 31, 2020. RESULTS: The least squares mean TKV ratio (TKV at each time point/TKV at dialysis initiation) was 63.8% (95% confidence interval [CI], 54.7%-72.9%) at 6 years before dialysis initiation and 95.5% (95% CI, 82.9%-108.2%) at 6 years after dialysis initiation (P<.001). A multivariate linear mixed model analysis revealed that dialysis style (HD or PD) had the strongest effect on changes in TKV (P=.002). The least squares mean TLV ratio was 98.2% (95% CI, 88.4%-108.0%) at 6 years before dialysis initiation and 95.7% (95% CI, 85.2%-106.2%) at 6 years after dialysis initiation (P=.01). Although PD did not have significant effects on changes in TLV (P=.27), the changes in TLV were greater in patients on PD than in those on HD. CONCLUSION: The TKV increased until dialysis initiation and generally decreased after dialysis initiation. The TLV continued to increase even after dialysis initiation, however, changes in the TLV significantly decreased after dialysis initiation. The increases in TKV and TLV were greater in patients on PD than in those on HD.
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spelling pubmed-98739482023-01-26 Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation Suwabe, Tatsuya Ubara, Yoshifumi Oba, Yuki Mizuno, Hiroki Ikuma, Daisuke Yamanouchi, Masayuki Sekine, Akinari Tanaka, Kiho Hasegawa, Eiko Hoshino, Junichi Sawa, Naoki Mayo Clin Proc Innov Qual Outcomes Original Article OBJECTIVE: To examine the changes in total kidney volume (TKV) and total liver volume (TLV) before and after dialysis initiation in patients with autosomal dominant polycystic kidney disease. PATIENTS AND METHODS: This was a retrospective, single-center cohort study to investigate the changes in TKV and TLV before and after dialysis initiation, along with influencing factors, using linear mixed models. We enrolled 95 patients with autosomal dominant polycystic kidney disease (85 receiving hemodialysis [HD] and 10 receiving peritoneal dialysis [PD]) who began receiving dialysis at Toranomon Hospital from January 1, 2008, to December 31, 2020. RESULTS: The least squares mean TKV ratio (TKV at each time point/TKV at dialysis initiation) was 63.8% (95% confidence interval [CI], 54.7%-72.9%) at 6 years before dialysis initiation and 95.5% (95% CI, 82.9%-108.2%) at 6 years after dialysis initiation (P<.001). A multivariate linear mixed model analysis revealed that dialysis style (HD or PD) had the strongest effect on changes in TKV (P=.002). The least squares mean TLV ratio was 98.2% (95% CI, 88.4%-108.0%) at 6 years before dialysis initiation and 95.7% (95% CI, 85.2%-106.2%) at 6 years after dialysis initiation (P=.01). Although PD did not have significant effects on changes in TLV (P=.27), the changes in TLV were greater in patients on PD than in those on HD. CONCLUSION: The TKV increased until dialysis initiation and generally decreased after dialysis initiation. The TLV continued to increase even after dialysis initiation, however, changes in the TLV significantly decreased after dialysis initiation. The increases in TKV and TLV were greater in patients on PD than in those on HD. Elsevier 2023-01-20 /pmc/articles/PMC9873948/ /pubmed/36712823 http://dx.doi.org/10.1016/j.mayocpiqo.2022.12.005 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Suwabe, Tatsuya
Ubara, Yoshifumi
Oba, Yuki
Mizuno, Hiroki
Ikuma, Daisuke
Yamanouchi, Masayuki
Sekine, Akinari
Tanaka, Kiho
Hasegawa, Eiko
Hoshino, Junichi
Sawa, Naoki
Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation
title Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation
title_full Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation
title_fullStr Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation
title_full_unstemmed Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation
title_short Changes in Kidney and Liver Volumes in Patients With Autosomal Dominant Polycystic Kidney Disease Before and After Dialysis Initiation
title_sort changes in kidney and liver volumes in patients with autosomal dominant polycystic kidney disease before and after dialysis initiation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873948/
https://www.ncbi.nlm.nih.gov/pubmed/36712823
http://dx.doi.org/10.1016/j.mayocpiqo.2022.12.005
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