Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets

Systemic lupus erythematosus (SLE) is characterized by increased expression of type I interferon (IFN)-regulated genes in 50%–75% of patients. We report that out of 501 patients with SLE analyzed, 73 (14%) present autoantibodies against IFNα (anti-IFN-Abs). The presence of neutralizing-anti-IFN-Abs...

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Detalles Bibliográficos
Autores principales: Bradford, Hannah F., Haljasmägi, Liis, Menon, Madhvi, McDonnell, Thomas C.R., Särekannu, Karita, Vanker, Martti, Peterson, Pärt, Wincup, Chris, Abida, Rym, Gonzalez, Raquel Fernandez, Bondet, Vincent, Duffy, Darragh, Isenberg, David A., Kisand, Kai, Mauri, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873953/
https://www.ncbi.nlm.nih.gov/pubmed/36652906
http://dx.doi.org/10.1016/j.xcrm.2022.100894

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