Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

The non-canonical inflammasome sensor caspase-11 and gasdermin D (GSDMD) drive inflammation and pyroptosis, a type of immunogenic cell death that favors cell-mediated immunity (CMI) in cancer, infection, and autoimmunity. Here we show that caspase-11 and GSDMD are required for CD8(+) and Th1 respons...

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Detalles Bibliográficos
Autores principales: Muñoz-Wolf, Natalia, Ward, Ross W., Hearnden, Claire H., Sharp, Fiona A., Geoghegan, Joan, O’Grady, Katie, McEntee, Craig P., Shanahan, Katharine A., Guy, Coralie, Bowie, Andrew G., Campbell, Matthew, Roces, Carla.B., Anderluzzi, Giulia, Webb, Cameron, Perrie, Yvonne, Creagh, Emma, Lavelle, Ed C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873954/
https://www.ncbi.nlm.nih.gov/pubmed/36652908
http://dx.doi.org/10.1016/j.xcrm.2022.100899

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