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Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of t...

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Autores principales: Huang, Xue-Yan, Xue, Lu-Lu, Chen, Ting-Bao, Huangfu, Li-Ren, Wang, Ting-Hua, Xiong, Liu-Lin, Yu, Chang-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873977/
https://www.ncbi.nlm.nih.gov/pubmed/36712676
http://dx.doi.org/10.3389/fphar.2022.1080753
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author Huang, Xue-Yan
Xue, Lu-Lu
Chen, Ting-Bao
Huangfu, Li-Ren
Wang, Ting-Hua
Xiong, Liu-Lin
Yu, Chang-Yin
author_facet Huang, Xue-Yan
Xue, Lu-Lu
Chen, Ting-Bao
Huangfu, Li-Ren
Wang, Ting-Hua
Xiong, Liu-Lin
Yu, Chang-Yin
author_sort Huang, Xue-Yan
collection PubMed
description Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of this study was to provide data resources and a potential drug for treatment of AD. An AD mouse model was established and treated with MFSs for 1 month. The Morris water maze test was used to assess learning memory function in mice. Nissl staining was used to demonstrate histopathological changes. MFSs were found to have therapeutic implications in the AD mouse model, as evidenced by improved learning memory function and an increase in surviving neurons. To explore the mechanism of MFSs in treating AD, network pharmacological approaches, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking studies were carried out. Based on the network pharmacology strategy, 74 components from MFS corresponded to 293 targets related to the AD pathology. Among these targets, AKT1, MAPK3, ESR1, PPARG, PTGS2, EGFR, PPARA, CNR1, ABCB1, and MAPT were identified as the core targets. According to the relevant number of core targets, cis-8-octadecenoic acid, cis-10-octadecenoic acid, 2-dodecenal, and tetradecane are likely to be highly correlated with MFS for AD. Enrichment analysis indicated the common targets mainly enriched in AD and the neurodegeneration-multiple disease signaling pathway. The molecular docking predictions showed that MFSs were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. MFSs may play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway. The findings of this study provide potential possibilities and drug candidates for the treatment of AD.
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spelling pubmed-98739772023-01-26 Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease Huang, Xue-Yan Xue, Lu-Lu Chen, Ting-Bao Huangfu, Li-Ren Wang, Ting-Hua Xiong, Liu-Lin Yu, Chang-Yin Front Pharmacol Pharmacology Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of this study was to provide data resources and a potential drug for treatment of AD. An AD mouse model was established and treated with MFSs for 1 month. The Morris water maze test was used to assess learning memory function in mice. Nissl staining was used to demonstrate histopathological changes. MFSs were found to have therapeutic implications in the AD mouse model, as evidenced by improved learning memory function and an increase in surviving neurons. To explore the mechanism of MFSs in treating AD, network pharmacological approaches, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking studies were carried out. Based on the network pharmacology strategy, 74 components from MFS corresponded to 293 targets related to the AD pathology. Among these targets, AKT1, MAPK3, ESR1, PPARG, PTGS2, EGFR, PPARA, CNR1, ABCB1, and MAPT were identified as the core targets. According to the relevant number of core targets, cis-8-octadecenoic acid, cis-10-octadecenoic acid, 2-dodecenal, and tetradecane are likely to be highly correlated with MFS for AD. Enrichment analysis indicated the common targets mainly enriched in AD and the neurodegeneration-multiple disease signaling pathway. The molecular docking predictions showed that MFSs were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. MFSs may play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway. The findings of this study provide potential possibilities and drug candidates for the treatment of AD. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9873977/ /pubmed/36712676 http://dx.doi.org/10.3389/fphar.2022.1080753 Text en Copyright © 2023 Huang, Xue, Chen, Huangfu, Wang, Xiong and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Huang, Xue-Yan
Xue, Lu-Lu
Chen, Ting-Bao
Huangfu, Li-Ren
Wang, Ting-Hua
Xiong, Liu-Lin
Yu, Chang-Yin
Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
title Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
title_full Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
title_fullStr Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
title_full_unstemmed Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
title_short Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
title_sort miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in alzheimer’s disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873977/
https://www.ncbi.nlm.nih.gov/pubmed/36712676
http://dx.doi.org/10.3389/fphar.2022.1080753
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